51417-51-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51417-51-7,7-Bromoindole,as a common compound, the synthetic route is as follows.
General procedure: Under a nitrogen stream, 5-bromo-1H-indole (25g, 0.128mol), 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi(1,3,2-dioxaborolane)(48.58g, 0.191mol), Pd (dppf) Cl2 (5.2g, 5mol), KOAc (37.55g, 0.383mol), and 1,4-dioxane (500ml) mixed, and the mixture was stirred for 12 hours at 130C .After completion of the reaction, and extracted with ethyl acetate, water was removed by MgSO4, column chromatography (hexane: EA = 10: 1 (v / v)) purified to at 5- (4,4,5,5-tetra to give methyl 1,3,2-dioxaborolan-2-yl)-lH-indole (22.32g, 72% yield).7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indolewas obtained by performing the same procedure as in ofPreparation Example 1, except that 7-bromo-1H-indole was used insteadof 5-bromo-1H-indole.
The synthetic route of 51417-51-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DOOSAN CORPORATION; PARK, HO CHEOL; BAE, HYUNG CHAN; EUM, MIN SIK; BEAK, YOUNG MI; LEE, CHANG JUN; SHIN, JIN YONG; KIM, TAE HYUNG; (163 pag.)JP2015/528445; (2015); A;,
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