5192-23-4, 4-Aminoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4. To a solution of Compound 4 (500 mg, 2.57 mmol) in DCM (10 mL) were added 4- aminoindole (340 mg, 2.57 mmol), EDCI (1 g, 5.14 mmol) and DMAP (80 mg). The reaction mixture was stirred at RT overnight. TLC indicated reaction completion. The residue was treated with water and extracted with DCM. The organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated to give a crude oil. The crude product was purified by silica gel chromatography to afford Example 43 (200 mg, 25.2%). 1HNMR (CDCI3, 300 MHz) delta: 1.3-1.4 (d, 3 H), 2.6-3.0 (m, 2 H), 3.7-3.9 (m, 4 H), 6.8- 7.0 (m, 2 H), 7.2-7.5 (m, 5 H), 7.6-7.8 (m, 1H). 8.2-8.3 (m, 1 H). LC-MS: m/z= 309.3 (M+l) +.
5192-23-4, As the paragraph descriping shows that 5192-23-4 is playing an increasingly important role.
Reference£º
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; KOYUNCU, Emre; SUN, Qun; CHIANG, Lillian; (133 pag.)WO2016/77240; (2016); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles