In an article, author is Huang, Tongkun, once mentioned the application of 530-78-9, Name is Flufenamic acid, molecular formula is C14H10F3NO2, molecular weight is 281.2299, MDL number is MFCD00002422, category is indole-building-block. Now introduce a scientific discovery about this category, Recommanded Product: Flufenamic acid.
C7-Functionalization of Indoles via Organocatalytic Enantioselective Friedel-Crafts Alkylation of 4-Aminoindoles with 2-Butene-1,4-diones and 3-Aroylacrylates
An efficient protocol for the enantioselective C7 Friedel-Crafts alkylation between 4-aminoindoles and 2-butene-1,4-diones or 3-aroylacrylates was reported. This process was catalyzed by a chiral phosphoric acid, affording the corresponding 1,4-disubstituted indoles in moderate to high yields with good to high enantioselectivities. This reaction could be performed on a gram scale without loss of efficiency, and a representative derivatization of the products was also investigated to prepare the corresponding C3 formylation compound.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles