With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53330-94-2,1-(1H-Indol-5-yl)ethanone,as a common compound, the synthetic route is as follows.
To a solution of 24 (500 mg, 3.14 mmol) in 20 mL anhydrous THF,NaH (60%, 188 mg, 4.71 mmol) was added and the mixture wasstirred for 15 min. Then, (Boc)2O (822 mg, 4.71 mmol) was addeddropwise. After stirring for 1 h, the mixture was diluted with 50 mLEtOAc, then washed with water (20 mL x 3), saturated brine, driedover anhydrous Na2SO4, and concentrated in vacuo to afford thecrude product, which was purified by column chromatographywith petroleum/ethyl acetate (5:1) to give intermediate 21a(650 mg, 79.9%). The spectral data of 21c was in accordance withliterature report [36].
53330-94-2 1-(1H-Indol-5-yl)ethanone 40732, aindole-building-block compound, is more and more widely used in various.
Reference£º
Article; Li, Wenlong; Shuai, Wen; Sun, Honghao; Xu, Feijie; Bi, Yi; Xu, Jinyi; Ma, Cong; Yao, Hequan; Zhu, Zheying; Xu, Shengtao; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 428 – 442;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles