With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5457-28-3,1H-Indole-3-carbonitrile,as a common compound, the synthetic route is as follows.
To a 1 L four-neck flask were added dioxane (200 mL), THF (100 mL) and 3- cyanoindole (30 g, 211 mmol). The solution was cooled to 0 oC and LiAlH4 (30 g, 780 mmol) was added portion-wise. After stirring at 0 oC for 10 minutes, the mixture was heated to reflux for 0.5 h until TLC showed completion. The mixture was carefully quenched with water (300 mL) at 0 oC, filtered, and the filtrate was separated. The aqueous layer was extracted with EA (500 mL x 2). The combined organic layers were dried over sodium sulfate, concentrated and washed with PE/EA to give 3-aminomethylindole (21 g, 70percent) as a brick red solid. (2137) 1H NMR (300 MHz, DMSO-d6) 10.80 (br, 1 H), 7.59 (d, J = 7.5 Hz, 1 H), 7.34 (d, J = 8.1 Hz, 1 H), 7.20 (s, 1 H), 7.09- 7.04 (m, 1 H), 6.99- 6.94 (m, 1 H), 3.87 (s, 2 H)., 5457-28-3
5457-28-3 1H-Indole-3-carbonitrile 230282, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; CS PHARMASCIENCES, INC.; SONG, Yuntao; BRDIGES, Alexander, James; (524 pag.)WO2017/120429; (2017); A1;,
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