With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.703-80-0,3-Acetylindole,as a common compound, the synthetic route is as follows.
703-80-0, To a solution of 3-acetylindole 8a (1.0 g, 6.3 mmol) in THF (5.0 mL) sodium hydride (60% dispersion in mineral oil, 0.3 g, 6.3 mmol) was added at 0 C and the mixture was stirred at room temperature for 1 h. p-toluenesulfonyl chloride (1.2 g, 6.3 mmol) was added and the mixture was stirred at room temperature for 24 h. The residue was evaporated under reduced pressure, treated with water (20 mL) and extracted with EtOAc (3 ¡Á 20 mL). The organic phase was dried (Na2SO4), evaporated under reduced pressure and purified by column chromatography using DCM as eluent. White solid; yield: 90%; mp: 148-149 C; IR 1662 (CO), 1382, 1299 (SO2) cm-1; 1H NMR (200 MHz, DMSO-d6) delta: 2.33 (s, 3H, CH3), 2.60 (s, 3H, CH3), 7.32-7.39 (m, 2H, H-5, H-6), 7.43 (d, 2H, J = 7.8 Hz, H-3?, H-5?), 7.95 (d, 1H, J = 7.5 Hz, H-7), 8.04 (d, 2H, J = 7.8 Hz, H-2?, H-6?), 8.19 (d, 1H, J = 7.5 Hz, H-4), 8.81 (s, 1H, H-2); 13C NMR (50 MHz, DMSO-d6) delta:21.0 (q), 27.8 (q), 113.0 (d), 120.7 (s), 122.3 (d), 124.8 (d), 125.6 (d), 127.0 (s), 127.2 (2xd), 130.5 (2xd), 133.5 (s), 134.0 (s), 134.2 (d), 146.2 (s), 193.9 (s). Anal. Calcd for: C17H15NO3S: C, 65.16; H, 4.82; N, 4.47. Found: C, 65.28, H, 5.06, N, 4.37.
703-80-0 3-Acetylindole 12802, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Parrino, Barbara; Carbone, Anna; Di Vita, Gloria; Ciancimino, Cristina; Attanzio, Alessandro; Spano, Virginia; Montalbano, Alessandra; Barraja, Paola; Tesoriere, Luisa; Livrea, Maria Antonia; Diana, Patrizia; Cirrincione, Girolamo; Marine Drugs; vol. 13; 4; (2015); p. 1901 – 1924;,
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