With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-37-8,Indole-3-acetamide,as a common compound, the synthetic route is as follows.,879-37-8
To a solution of 5, 6-dihydro-4H-pyrrolo [3,2,1-//] quinolin-1-yl) oxoacetic acid methyl ester (1.0 g, 4.12 mmol) and indole-3-acetamide (0.8 g, 4.5 mmol) in anhydrous tetrahydrofuran at O0C was added a solution of potassium t-butoxide (IM in tetrahydrofuran) (12.4 ml, 12.4 mmol) dropwise over 30 minutes. The mixture was stirred at 0 C for 2 hours. Concentrated hydrochloric acid (10 ml) was then added and the mixture stirred for 1 hour at room temperature. The mixture was then diluted with ethyl acetate (200 ml), washed twice with water (50 ml), and saturated aqueous sodium chloride solution (50 ml) and the organic layer dried over anhydrous sodium sulfate. The residue was purified by silica gel chromatography, eluting with ethyl acetate/hexanes (1:4) to afford 3-(5,6-dihydro-4H- pyrrolo [3,2,1-?)’] quinolin-l-yl)-4(lH-indol-3-yl) pyrrole-2, 5-dione as a bright red solid (1.2 g, 80 %). 1H NMR (CDCl3) 400 MHz delta: 8.5(brs, IH), 7.78(s, IH), 7.63(d, IH, J=2.8 Hz), 7.44(s, IH), 7.35(d, IH, J=8 Hz), 7.16(d, IH, J=8.4 Hz), 7.1 l(t, IH, J=7.6 Hz), 6.86 (t, IH, J=7.6 Hz), 6.80(d, IH, J=7.2 Hz),6.64(t, IH, J=8 Hz), 6.57(d, IH, J=8 Hz), 4.2(t, 2H, J=6 Hz), 2.96(t, 2H, J=6 Hz), 2.24(m, 2H).
As the paragraph descriping shows that 879-37-8 is playing an increasingly important role.
Reference：
Patent; ARQULE, INC.; WO2006/86484; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles