With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885520-70-7,4-Bromo-6-fluoro-1H-indole,as a common compound, the synthetic route is as follows.
885520-70-7, To a solution of 4-bromo-6-fluoro-lH-indole (6.0 g, 25.53 mmol) and bis(pinacolato)diboron (9.7 g, 38.19 mmol) in anhydrous DMSO (120 mL) were added KOAc (7.5 g, 76.41 mmol) and [l,r-bis(diphenylphosphine)ferrocene]-dichloropalladium (1.0 g, 1.22 mmol). The mixture was heated at 80 ¡ãC for 18 h. The reaction mixture was cooled to RT and partioned between EtOAc and H2O. The organic layer was washed successively with H2O and brine, dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by column chromatography (silica gel, pentane:EtOAc 75:25) to provide the title compound as a white solid (4.6 g, 61 percent).NMR deltaH (300 MHz, CDCl3) 1.39 (s, 12H), 7.02 (m, IH), 7.14-7.19 (m, IH), 7.20-7.26 (m, IH), 7.38 (dd, J = 2.4, 9.9, IH) and 8.16 (s, IH).
As the paragraph descriping shows that 885520-70-7 is playing an increasingly important role.
Reference£º
Patent; F.HOFFMANN-LA ROCHE AG; WO2008/152390; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles