90923-75-4, 1-Methyl-1H-indole-5-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of AB-region starting material (1.0 equiv) in THF was added dropwise 2.5 M n-BuLi solution in n-hexane (1.05 equiv) at -78 C. The reaction mixture was stirred for 10 min at -78 C, and DE-region aldehyde (1.0 equiv) was added. The reaction mixture was stirred for an additional 30 min and was warmed to ambient temperature. The reaction mixture was quenched with saturated NH4Cl solution and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to afford the corresponding compound.
90923-75-4 1-Methyl-1H-indole-5-carbaldehyde 7537534, aindole-building-block compound, is more and more widely used in various.
Reference£º
Article; Kim, Ho Shin; Hong, Mannkyu; Ann, Jihyae; Yoon, Suyoung; Nguyen, Cong-Truong; Lee, Su-Chan; Lee, Ho-Young; Suh, Young-Ger; Seo, Ji Hae; Choi, Hoon; Kim, Jun Yong; Kim, Kyu-Won; Kim, Joohwan; Kim, Young-Myeong; Park, So-Jung; Park, Hyun-Ju; Lee, Jeewoo; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 6082 – 6093;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles