91348-45-7, Ethyl 3-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,91348-45-7
Production Example 9-1 ethyl 3-(3-furyl)-1H-indole-2-carboxylate A toluene-ethanol mixed solvent (1:1, 60 mL) containing commercially available ethyl 3-bromo-1H-indole-2-carboxylate (1.5 g), 3-furylboronic acid (939 mg), tetrakis(triphenylphosphine)palladium(0) (1.29 g) and a 1 M aqueous sodium carbonate solution (11.2 mL) was heated under reflux overnight at 100 C. under a nitrogen atmosphere. The reaction solution was concentrated under reduced pressure, and to the residue, water was added and the solution was extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1), whereby the title compound (340 mg) was obtained as a pale yellow solid.
91348-45-7 Ethyl 3-bromo-1H-indole-2-carboxylate 4715017, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles