938465-52-2, 1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
938465-52-2, To a solution of (S)-2-(4-fluorophenyl)-2,8-diazaspiro[5.Sjundecan-1-one (120 mg, 0.45 mmol) in NMP (3 mL) was added 1-chloro-5H-pyrido[4,3-bjindole-4-carboxamide(Intermediate 1, 123 mg, 0.Smmol) and DIPEA (174 mg, 1.35 mmol), and the mixture was heated under microwave irradiation for 1.5 h at 150 C.The mixture was purified with prepHPLC to give (R)- 1 -(8-(4-fluorophenyl)-7-oxo-2, 8-diazaspiro[5 .51 undecan-2-yl)-5H-pyrido [4,3- bjindole-4-carboxamide. MS: 472.3 [M+Hjt 1H NMR (400 MHz, CD3OD) 3 8.45 (s, 1H), 8.03 (d, fr8.0 Hz, 1H), 7.81 (d, fr8.0 Hz, 1H), 7.62 (t, J=7.3 Hz, 1H), 7.55 – 7.49 (m, 1H), 7.11 – 7.06(m, 4H), 4.28 (d, J=12.5 Hz, 1H), 4.03 – 3.93 (m, 1H), 3.87 (d, fr12.5 Hz, 1H), 3.80 (d, fr4.8Hz, 1H), 3.63 – 3.53 (m, 2H), 2.43 (ddd, fr4.8, 7.7, 12.9 Hz, 1H), 2.25 – 2.07 (m, 3H), 2.07 -1.98 (m, 3H), 1.94 – 1.84 (m, 1H) ppm.
938465-52-2 1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide 59198457, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph; KIM, Ronald; GAO, Xiaolei; BOGA, Sobhana Babu; YU, Younong; WU, Hao; LIU, Shilan; YANG, Chundao; (102 pag.)WO2016/164284; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles