Authors Kim, SK; Lee, S; Lee, MK; Lee, S in ELSEVIER IRELAND LTD published article about ANGIOTENSIN-ALDOSTERONE SYSTEM; TUBULOINTERSTITIAL FIBROSIS; MAJOR COMPONENT; NA+,K+-ATPASE ACTIVITY; ORAL BIOAVAILABILITY; DRUG DISCOVERY; RAS INHIBITOR; FATTY LIVER; CALCIUM; CINNAMALDEHYDE in [Kim, Sang-Kyun; Lee, Seungho; Lee, Myung-Ku; Lee, Sanghun] Korea Inst Oriental Med, Future Med Div, 1672 Yuseong Daero, Daejeon 34054, South Korea in 2019.0, Cited 76.0. Product Details of 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Ethnopharmacological relevance: Oryeong-san (ORS) is a traditional formula that has long been used for the treatment of dysfunctions of body fluids and electrolyte homeostasis in Korea, China and Japan. Recent reports have shown that ORS may suppress hypertension by controlling the renin-angiotensin-aldosterone system (RAAS) in the kidney, but its action mechanism has not been well defined. Aim of the study: The aim of this study was to decipher the ORS mechanisms in the treatment of hypertension using a systems pharmacology approach. Materials and methods: The compounds of ORS were obtained from the TM-MC (database of medicinal materials and chemical compounds in Northeast Asian traditional medicine), and the drug-likeness (DL) and oral bioavailability (OB) of the compounds were evaluated. The potential targets of the compounds were identified using various pharmacology databases. To analyze the mechanisms of the ORS for hypertension, a Compound-Target Disease (C-T-D) network was established with respect to the genes related to hypertension. Results: A screening evaluation of the DL and OB of the ORS compounds identified a list of 232 active compounds. The pharmacological activity of the targets was investigated by exploring the interaction network between the compounds and the targets. Analysis of the interactions between the compounds and the hypertension related targets revealed that 14 ORS compounds regulate the RAAS and vasoconstrictors in the kidney. Conclusions: This study used the systems pharmacology approach to decipher the mechanisms of action of ORS for the treatment of hypertension. When hypertension drugs and ORS are used in combination for treatment, possible side effects should be considered because most hypertension drugs are related to the RAAS. The results of this study may provide clues to not only analyze the pharmacological activity of ORS for the treatment of hypertension but other diseases as well.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles