In 2021.0 J ORG CHEM published article about OXOCARBENIUM IONS; DOXORUBICIN; ALKYNYLBENZOATES; DAUNORUBICIN; DAUNOSAMINE; DERIVATIVES; SUBSTITUENT in [Wander, Dennis P. A.; Vriends, Merijn B. L.; van Veen, Branca C.; Vlaming, Joey G. C.; Bruyning, Thomas; Hansen, Thomas; van der Marel, Gijsbert A.; Overkleeft, Herman S.; Codee, Jeroen D. C.] Leiden Univ, Leiden Inst Chem, NL-2333 CC Leiden, Netherlands; [van der Zanden, Sabina Y.; Neefjes, Jacques J. C.] Leiden Univ, ONCODE Inst, Med Ctr, NL-2333 ZC Leiden, Netherlands; [Hansen, Thomas] Vrije Univ Amsterdam, Amsterdam Ctr Multiscale Modeling ACMM, Amsterdam Inst Mol & Life Sci AIMSS, Dept Theoret Chem, NL-1081 HV Amsterdam, Netherlands in 2021.0, Cited 32.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5. HPLC of Formula: C7H8O2
Anthracyclines are effective drugs in the treatment of various cancers, but their use comes with severe side effects. The archetypal anthracycline drug, doxorubicin, displays two molecular modes of action: DNA double-strand break formation (through topoisomerase II alpha poisoning) and chromatin damage (via eviction of histones). These biological activities can be modulated and toxic side effects can be reduced by separating these two modes of action through alteration of the aminoglycoside moiety of doxorubicin. We herein report on the design, synthesis, and evaluation of a coherent set of configurational doxorubicin analogues featuring all possible stereoisomers of the 1,2-amino-alcohol characteristic for the doxorubicin 3-amino-2,3-dideoxyfucoside, each in nonsubstituted and N,N-dimethylated forms. The set of doxorubicin analogues was synthesized using appropriately protected 2,3,6-dideoxy-3-amino glycosyl donors, equipped with an alkynylbenzoate anomeric leaving group, and the doxorubicin aglycon acceptor. The majority of these glycosylations proceeded in a highly stereoselective manner to provide the desired axial alpha-linkage. We show that both stereochemistry of the 3-amine carbon and N-substitution state are critical for anthracycline cytotoxicity and generally improve cellular uptake. N,N-Dimethylepirubicin is identified as the most potent anthracycline that does not induce DNA damage while remaining cytotoxic.
Welcome to talk about 150-76-5, If you have any questions, you can contact Wander, DPA; van der Zanden, SY; Vriends, MBL; van Veen, BC; Vlaming, JGC; Bruyning, T; Hansen, T; van der Marel, GA; Overkleeft, HS; Neefjes, JJC; Codee, JDC or send Email.. HPLC of Formula: C7H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles