Expedient synthesis of 1-hydroxy-4- and 1-hydroxy-6-nitroindoles was written by Bujok, Robert;Wrobel, Zbigniew;Wojciechowski, Krzysztof. And the article was included in Synlett in 2012.HPLC of Formula: 3484-23-9 This article mentions the following:
Reaction of 伪-chloroalkyl ketones with 1,3-dinitrobenzenes provided 2,4-dinitrobenzyl ketones, which on reduction with SnCl2 gave 6-nitro derivatives of 1-hydroxyindoles. An alternative approach is the condensation of 2,4- and 2,6-dinitrotoluenes with (CO2Et)2 or F3CCO2Et to yield dinitrobenzyl ketones, which on reduction with SnCl2 afforded nitro derivatives of 1-hydroxyindol-2-carboxylates or 1-hydroxy-2-(trifluoromethyl)indoles, resp. In the experiment, the researchers used many compounds, for example, 2-Methyl-6-nitro-1H-indole (cas: 3484-23-9HPLC of Formula: 3484-23-9).
2-Methyl-6-nitro-1H-indole (cas: 3484-23-9) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 3484-23-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles