Cai, Xianrong; Wang, Chao; Sun, Jian published an article in 2012, the title of the article was Organocatalytic Enantioselective Dipolar [3+2] Cycloadditions of Acetylenic Aldehydes with Nitrones for the Formation of Chiral 4-Isoxazolines.Name: H-Idc-OH And the article contains the following content:
An organocatalytic enantioselective protocol has been developed for the dipolar [3+2] cycloaddition between acetylenic aldehydes and nitrones through an iminium activation pathway. This protocol uses L-α,α-bis(3,5-ditrifluoromethylphenyl)prolinol as catalyst and 3,5-dinitrobenzoic acid as additive and is friendly for one-pot operation for the nitrone formation and the subsequent cycloaddition It also exhibits a broad substrate scope and allows for the highly efficient production of chiral 4-isoxazolines with various substituents under mild conditions in high yields (68-92%) with high enantioselectivities (up to 96% ee). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Name: H-Idc-OH
The Article related to isoxazoline stereoselective preparation alkynal aldehyde nitrone prolinol catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Name: H-Idc-OH
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles