Safety of 3-Hydroxybenzaldehyde. In 2020.0 ORG LETT published article about ASYMMETRIC CONJUGATE REDUCTION; BITE ANGLE; C-C; REGIOSELECTIVE SYNTHESIS; CONVENIENT SYNTHESIS; TANDEM REACTION; ACID CATALYSTS; CYCLIZATION; EFFICIENT; ALDEHYDES in [Jang, Su San; Kim, Young Ho; Youn, So Won] Hanyang Univ, Ctr New Direct Organ Synth, Dept Chem, Seoul 04763, South Korea; [Jang, Su San; Kim, Young Ho; Youn, So Won] Hanyang Univ, Res Inst Nat Sci, Seoul 04763, South Korea in 2020.0, Cited 104.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.
Pd-catalyzed annulative couplings of 2-alkenylanilines with aldehydes using alcohols as both the solvent and hydrogen source have been developed. These domino processes allow divergent syntheses of two significant N-heterocycles, indoles and quinolines, from the same substrate by tuning reaction parameters, which seems to invoke two distinct mechanisms. The nature of the ligand and alcoholic solvent had a profound influence on the selectivity and efficiency of these protocols. Particularly noteworthy is that indole formation was achieved by overcoming two significant challenges, regioselective hydropalladation of alkenes and subsequent reactions between the resulting Csp(3)-Pd species and less reactive imines.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles