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A series of 5-(piperidinylethyloxy)quinoline 5-hydroxytryptamine 1D (5-HT1D) receptor antagonists have been discovered from elaboration of the series of dual 5-hydroxytryptamine1-selective serotonin reuptake inhibitors (5HT1-SSRIs) reported previously. This is the first report of highly potent, selective antagonists for the 5-HT 1D receptor, which represents an extremely useful set of pharmacological tools for further understanding the roles of the 5-HT 1 receptor subtypes.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles