Electric Literature of C12H9N3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Weinreb amide as an efficient reagent in the one pot synthesis of benzimidazoles and benzothiazoles. Author is Bommegowda, Yadaganahalli K.; Lingaraju, Gejjalagere S.; Thamas, Saji; Vinay Kumar, Koravangala S.; Pradeepa Kumara, Challanayakanahally S.; Rangappa, Kanchugarakoppal S.; Sadashiva, Marilinganadoddi P..
One pot synthesis of 2-substituted benzimidazoles/benzothiazoles through condensation is followed by cyclization of Weinreb amide with o-diaminoarene or o-aminothiophenol is reported. In the presence of boron trifluoride etherate in 1,4-dioxane solvent, a high yield (75-94%) was achieved within 60 min. Weinreb amide shows high selectivity in the reaction, even in presence of other active functional groups such as carboxyl, halogen, cyano, and methoxy.
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