Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Recommanded Product: Ethyl indole-2-carboxylate, Which mentioned a new discovery about 3770-50-1
Appropriate and fine-tuned treatments of amorphous carbon (AC) involving aqua regia or concentrated HNO3 lead to oxidised carbon materials (oAC) which are able to catalyse 2,2?- and 3,3?-homocouplings of various functionalised indoles with outstanding activity. This newly developed carbocatalysed Csp2-Csp2 bond formation can be achieved under mild thermal conditions. The study on the scope of the reaction revealed that the reaction can be extended to the homocoupling of other substrates of high synthetic interest such as 2-naphthol, 2-functionalised benzofurans and benzothiofurans. The characterisation of oAC with XPS together with ad hoc experiments aimed at blocking the active site revealed that the presence and distribution of C-O functionalities is critical and correlates well with the catalytic activity. Such experiments provide solid support for elucidation of the mechanism, suggesting a quinone nature of the active C-O groups, which are spontaneously regenerated by oxygen. This is confirmed by the fact that 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) is able to promote the coupling in a stoichiometric fashion.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Recommanded Product: Ethyl indole-2-carboxylate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 3770-50-1
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles