The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 348640-06-2, Name is 4-Bromo-7-azaindole, SMILES is BrC1=C2C(=NC=C1)[NH]C=C2, in an article , author is Liu, Jiaxin, once mentioned of 348640-06-2, HPLC of Formula: C7H5BrN2.
Visible-Light-Induced Trifluoromethylation of Isonitrile-Substituted Indole Derivatives: Access to 1-(Trifluoromethyl)-4,9-dihydro-3H-pyrido[3,4-b]indole and beta-Carboline Derivatives
A visible-light-induced trifluoromethylation of isonitrile-substituted indole derivatives has been developed from the reaction of isonitrile-substituted indoles with Togni II reagent, affording 1-(trifluoromethyl)-4,9-dihydro-3H-pyrido[3,4-b] indoles in moderate to good yields. The further transformations to beta-carboline derivatives and a harmacine derivative have been performed, demonstrating the potential synthetic utility of this method. A preliminary biological study indicated that the CF3-containing harmine analogue significantly stimulated the secretion of glucagon-like peptide-1 (GLP-1), suggesting an improvement in treating diabetes.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles