Chemistry is an experimental science, COA of Formula: C8H7NO, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1953-54-4, Name is 5-Hydroxyindole
Dearomatization-Rearomatization Strategy for Reductive Cross-Coupling of Indoles with Ketones in Water
N-Alkylation of indoles is one of the important pathways for the construction of various biologically active indole molecules. Using ketones as N-alkylation reagent for indoles has been a great challenge not only because of the competing alkylation reaction of C-3 position but also because of the poor nucleophilicity of the nitrogen atom of indole, in addition to the steric hindrance and lower electrophilicity of the ketones. A dearomatization-rearomatization strategy has been developed for reductive cross-coupling of indoles with ketones in water. Various functional groups and other heterocyclic compounds are tolerated.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C8H7NO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1953-54-4, in my other articles.
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles