Safety of Benzyl Alcohol. In 2021.0 RSC ADV published article about TERMINAL ARYL ALKENES; C-N; ANALOGS; CONDENSATION; DERIVATIVES; ACYLATION; C-SP3-H; ESTERS in [Sharma, Richa; Yadav, Lalit; Yadav, Ravi Kant; Chaudhary, Sandeep] Malaviya Natl Inst Technol, Dept Chem, Lab Organ & Med Chem OMC Lab, Jawaharlal Nehru Marg, Jaipur 302017, Rajasthan, India in 2021.0, Cited 42.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
An efficient, cost-effective, transition-metal-free, oxidative C-H cross-dehydrogenative coupling via a C-H bond functionalization protocol for the regioselective direct C-3 acylation/benzoylation of substituted 2H-Indazoles 1a-m with substituted aldehydes 2a-q/benzyl alcohols 5a-e/styrenes 6a-e is reported. The operationally simple protocol proceeds in the presence of tert-butyl peroxybenzoate (TBPB) as an oxidant in chlorobenzene (PhCl) as a solvent at 110 degrees C for 24 h under an inert atmosphere, which furnished a diverse variety of substituted 3-(acyl/benzoyl)-2H-indazoles 3a-q/4a-l in up to 87% yields. The reaction involves a free-radical mechanism and proceeds via the addition of an in situ generated acyl radical (from aldehydes/benzyl alcohols/styrenes) on 2H-indazoles. The functional group tolerance, broad substrate scope, control/competitive experiments and gram-scale synthesis and its application to the synthesis of anti-inflammatory agent 11 and novel indazole-fused diazepine 13 further signify the versatile nature of the developed methodology.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles