Backlund, CM; Parhamifar, L; Minter, L; Tew, GN; Andresen, TL in [Backlund, Coralie M.; Tew, Gregory N.] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA; [Minter, Lisa; Tew, Gregory N.] Univ Massachusetts, Dept Mol & Cellular Biol, Amherst, MA 01003 USA; [Minter, Lisa; Tew, Gregory N.] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA; [Parhamifar, Ladan; Andresen, Thomas L.] Tech Univ Denmark, Dept Hlth Technol, DK-2800 Lyngby, Denmark published Protein Transduction Domain Mimics Facilitate Rapid Antigen Delivery into Monocytes in 2019.0, Cited 37.0. Product Details of 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
Delivering peptides and proteins with intracellular function represents a promising avenue for therapeutics, but remains a challenge due to the selective permeability of the plasma membrane. The successful delivery of cytosolically active proteins would enable many opportunities, including improved vaccine development through major histocompatibility complex (MHC) class I antigen display. Extended research using cell-penetrating peptides (CPPs) has aimed to facilitate intracellular delivery of exogenous proteins with some success. A new class of polymer-based mimics termed protein transduction domain mimics (PTDMs), which maintain the positive charge and amphiphilic nature displayed by many CPPs, was developed using a poly-norbornene-based backbone. Herein, we use a previously characterized PTDM to investigate delivery of the model antigen SIINFEKL into leukocytes. Peptide delivery into over 90% of CD14+ monocytes was detected in less than 15 min with nominal inflammatory cytokine response and high cell viability. The co-delivery of a TLR9 agonist and antigen using the PTDM into antigen presenting cells in vitro showed presentation of SIINFEKL in association with MHC class I molecules, in addition to upregulation of classical differentiation markers revealing the ability of the PTDM to successfully deliver cargo intracellularly and show application in the field of immunotherapy.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles