Electric Literature of C9H9NO2In 2009, Powers, James J.;Favor, David A.;Rankin, Trent;Sharma, Rashmi;Pandit, Chetan;Jeganathan, Azhwarsamy;Maiti, Samarendra N. published 《Synthesis of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones》. 《Tetrahedron Letters》published the findings. The article contains the following contents:
The regioselective synthesis of a series of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones through a common aryl ester-nitrile intermediate is described. E.g., treatment of Me 2-cyano-5-methoxy-4-methylbenzoate (prepared from 3-methoxy-4-methylbenzoic acid via bromination, esterification, and cyanation) with Pd/C in ethanol gave the ring-closed 6-methoxy-5-methyl-2,3-dihydroisoindol-1-one. This was treated with boron tribromide in DCM to obtain 6-hydroxy-5-methyl-2,3-dihydroisoindol-1-one.6-Methoxyisoindolin-1-one (cas: 132680-54-7) were involved in the experimental procedure.
6-Methoxyisoindolin-1-one(cas:132680-54-7 Electric Literature of C9H9NO2) also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles