Smith, Keith;El-Hiti, Gamal A.;Hegazy, Amany S.;Kariuki, Benson published 《A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N’-benzyl-N,N-dimethylureas》. The research results were published in《Beilstein Journal of Organic Chemistry》 in 2011.Category: indole-building-block The article conveys some information:
Lithiation of N’-benzyl-N,N-dimethylurea and its substituted derivatives with (tert-butyl)lithium (3.3 equiv) in anhydrous THF at 0° followed by a reaction with various electrophiles afforded a range of 3-substituted isoindolinone derivatives in high yields.6-Methoxyisoindolin-1-one (cas: 132680-54-7) were involved in the experimental procedure.
6-Methoxyisoindolin-1-one(cas:132680-54-7 Category: indole-building-block) also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles