Electric Literature of C9H9NO2In 2017, Ling, Fei;Ai, Chongren;Lv, Yaping;Zhong, Weihui published 《Traceless Directing Group Assisted Cobalt-Catalyzed C-H Carbonylation of Benzylamines》. 《Advanced Synthesis & Catalysis》published the findings. The article contains the following contents:
An expedient and convenient strategy was reported for regioselective synthesis of N-unprotected isoindolinones I [R1 = H, 6-Me, 4-Br, etc.; R2 = H, Et, Ph, etc.] via Co-catalyzed C(sp2)-H carbonylation of benzylamines II using picolinamide as traceless directing group through direct C-H/N-H bond activation using DEAD as environmentally benign carbonyl source. This carbonylation strategy was also compatible with various aryl/heteroaryl substituted amines that afforded corresponding N-unprotected isoindolinones, e.g., III, thieno[2,3-c]pyrrol-4-one and 3,4-dihydroisoquinolin-1(2H)-one. This protocol tolerated a variety of functional groups and provided a facile and efficient method for the formal synthesis of (+)-garenoxacin. The experimental procedure involved many compounds, such as 6-Methoxyisoindolin-1-one (cas: 132680-54-7) .
6-Methoxyisoindolin-1-one(cas:132680-54-7 Electric Literature of C9H9NO2) also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles