Pan, Guoshuai;Lu, Leipeng;Zhuang, Weihui;Huang, Qiufeng published 《Synthesis of Indole-Fused Six-, Seven-, or Eight-Membered N,O-Heterocycles via Rhodium-Catalyzed NH-Indole-Directed C-H Acetoxylation/Hydrolysis/Annulation》 in 2021. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Application of 165669-07-8 The article mentions the following:
The facile synthesis of indole-fused six-, seven-, or eight-membered N,O-heterocycles I/II (R = H, Cl, Br) and III/IV and V through rhodium-catalyzed C-H acetoxylation/hydrolysis/annulation was reported. The notable features of this method include C-H acetoxylation using NH-indole as the intrinsic directing group, high functional group compatibility, and construction of indole-fused medium-sized rings. To complete the study, the researchers used 7-Bromo-4-methyl-1H-indole (cas: 165669-07-8) .
Application of 165669-07-8In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles