Yuan, Yumeng;Pan, Guoshuai;Zhang, Xiaofeng;Li, Buhong;Xiang, Shengchang;Huang, Qiufeng published 《Synthesis of seven-membered azepino[3,2,1-hi]indoles via rhodium-catalyzed regioselectively C-H activation/DBU-catalyzed intramolecualr amidation of 7-phenylindoles in one pot》. The research results were published in《Journal of Organic Chemistry》 in 2019.SDS of cas: 165669-07-8 The article conveys some information:
An unprecedented rhodium-catalyzed regioselectively C-H activation/DBU-catalyzed intramol. amidation cyclization of 7-arylindoles with diazomalonates is described that provides a straightforward route to seven-membered azepino[3,2,1-hi]indoles I (R1 = H, 12-Me, 11-F, etc.; R2 = 7-OMe, 7-tBu, 7-OH, etc.; R3 = CO2Me, CO2Et, CO2iPr) in good to excellent yields in one pot. A wide range of functional groups, including F, OMe, NPh2, SiMe3, Cl, CN, CHO, COMe, CO2Me, CF3, NO2 were all well tolerated.7-Bromo-4-methyl-1H-indole (cas: 165669-07-8) were involved in the experimental procedure.
SDS of cas: 165669-07-8In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles