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Recently I am researching about ANTITUMOR-ACTIVITY; ORGANIC-SYNTHESIS; GREEN SYNTHESIS; DERIVATIVES; ANTIOXIDANT; 4-HYDROXYCOUMARIN; CHEMISTRY; CANCER, Saw an article supported by the Special Assistance Programme SAP, University Grants Commission, New Delhi, India. Safety of 3-Hydroxybenzaldehyde. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Chate, AV; Shaikh, BA; Bondle, GM; Sangle, SM. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

The present work describes eco-friendly multicomponent protocol for the synthesis in excellent yields of structurally diverse benzylpyrazolyl coumarin 5 (a-s) involving the reaction of 4-hydroxycoumarin, ethyl acetoacetate, hydrazine hydrate/phenyl hydrazine hydrate and aldehydes, also novel pyrano[2,3-c]pyrazole derivatives 8 (a-k) integrated by isonicotinic acid hydrazide from reaction of aldehyde, ethyl acetoacetate, malononitrile with isoniazid, employing water as a reaction medium and 2-aminoethanesulfonic acid (taurine) as the catalyst. This new methodology endowed the advantages such as short reaction time, recovery of catalysts after catalytic reaction and reusing them without losing their activity and alleviate of operation. [GRAPHICS] .

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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An article Design and synthesis of leucine-linked quinazoline-4(3H)-one-sulphonamide molecules distorting malarial reductase activity in the folate pathway WOS:000478950800001 published article about DRUG-RESISTANCE; IONIC LIQUID; DIHYDROFOLATE-REDUCTASE; SULFONAMIDE; INHIBITORS; ANTICANCER; EFFICIENT; PARASITE; PREDICT; COMFA in [Patel, Tarosh S.; Dixit, Bharat C.] Sardar Patel Univ, VP&RPTP Sci Coll, Chem Dept, Vallabh Vidyanagar 388120, Gujarat, India; [Bhatt, Jaimin D.] Sardar Patel Univ, VP&RPTP Sci Coll, Ind Chem Dept, Vallabh Vidyanagar, Gujarat, India; [Dixit, Ritu B.] Ashok & Rita Patel Inst Integrated Studies & Res, Pharmaceut Chem Dept, New Vallabh Vidyanagar, Gujarat, India; [Chudasama, Chaitanya J.] Sardar Patel Univ, Shree Alpesh N Patel PG Inst, Dept Biochem, Anand, Gujarat, India; [Patel, Bhavesh D.] Sardar Patel Univ, VP&RPTP Sci Coll, Microbiol Dept, Vallabh Vidyanagar, Gujarat, India in 2019.0, Cited 60.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Optimization of a modified Grimmel’s method for N-heterocyclization of a leucine-linked sulfonamide side-arm at position 2 leading to 2,3-disustituted-4-quinazolin-(3H)-ones was accomplished. Further, 22 hybrid quinazolinone motifs (4a-v) were synthesized by N-heterocyclization reaction under microwave irradiation using the ionic liquid [Bmim][BF4]-H2O as green solvent as well as the catalyst. The in vitro screening of the hybrid entities against the malarial species Plasmodium falciparum yielded five potent molecules 4l, 4n, 4o, 4t, and 4u owning antimalarial activity comparable to those of the reference drugs. In continuation, an in silico study was carried out to obtain a pharmacophoric model and quantitative structure-activity relationship. We also built a 3D-QSAR model to procure more information that could be applied to design new molecules with more potent Pf-DHFR inhibitory activity. The designed pharmacophore was recognized to be more potent for the selected molecules, exhibiting five pharmacophoric features. The active scaffolds were further evaluated for enzyme inhibition efficacy against alleged receptor Pf-DHFR computationally and in vitro, proving their candidature as lead dihydrofolate reductase inhibitors, and the selectivity of the test candidates was ascertained by toxicity study against Vero cells. Good oral bioavailability was also proved by studying pharmacokinetic properties.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Welcome to talk about 100-83-4, If you have any questions, you can contact Liu, G; Yin, T; Kim, Y; Ding, CY; Yu, Z; Wang, H; Chen, HY; Yan, RP; Wold, EA; Zou, H; Liu, X; Ding, Y; Shen, Q; Zhou, J or send Email.. Recommanded Product: 3-Hydroxybenzaldehyde

In 2019.0 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; EXPRESSION; BCL-2; METASTASIS; APOPTOSIS; ANALOGS; GROWTH; TUMOR; CARBOPLATIN; COMBINATION in [Liu, Gang; Ding, Chunyong; Chen, Haiying; Wold, Eric A.; Ding, Ye; Zhou, Jia] Univ Texas Med Branch, Dept Pharmacol & Toxicol, Chem Biol Program, Galveston, TX 77555 USA; [Yin, Tao; Kim, Hyejin; Yu, Zhuo; Wang, Hong; Yan, Ruping; Zou, Hao; Liu, Xi; Shen, Qiang] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA in 2019.0, Cited 44.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde

In an effort to develop novel Bax activators for breast cancer treatment, a series of diverse analogues have been designed and synthesized based on lead compound SMBA1 through several strategies, including introducing various alkylamino side chains to have a deeper access to S184 pocket, replacing carbon atoms with nitrogen, and reducing the nitro group of 9H-fluorene scaffold. Compounds 14 (CYD-2-11) and 49 (CYD-4-61) have been identified to exhibit significantly improved antiproliferative activity compared to SMBA1, with IC50 values of 3.22 mu M and 0.07 mu M against triple-negative breast cancer MDA-MB-231 and 3.81 mu M and 0.06 mu M against ER-positive breast cancer MCF-7 cell lines, respectively. Mechanism of action studies of compound 49 indicated that it can activate Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis. Further in vivo efficacy studies of compounds 14 and 49 in nude mice bearing MDA-MB-231 tumor xenografts demonstrated that these drug candidates can significantly suppress tumor growth, indicating their therapeutic potential for the treatment of breast cancer. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 100-83-4, If you have any questions, you can contact Liu, G; Yin, T; Kim, Y; Ding, CY; Yu, Z; Wang, H; Chen, HY; Yan, RP; Wold, EA; Zou, H; Liu, X; Ding, Y; Shen, Q; Zhou, J or send Email.. Recommanded Product: 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Yahyazadehfar, M; Sheikhhosseini, E; Ahmadi, SA; Ghazanfari, D or concate me.

Yahyazadehfar, M; Sheikhhosseini, E; Ahmadi, SA; Ghazanfari, D in [Yahyazadehfar, Mahdieh; Sheikhhosseini, Enayatollah; Ahmadi, Sayed Ali; Ghazanfari, Dadkhoda] Islamic Azad Univ, Kerman Branch, Dept Chem, Kerman, Iran published Microwave-associate synthesis of Co3O4 nanoparticles as an effcient nanocatalyst for the synthesis of arylidene barbituric and Meldrum’s acid derivatives in green media in 2019.0, Cited 75.0. Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

In this study, Co3O4 nanocatalysts were constructed in environmentally appropriate conditions using controlled, effective, and facile microwave method. The final nanostructures were characterized by SEM, XRD, and TEM analyses. The products had a small size distribution, homogeneous morphology, and crystallographic structures associated with the formation of Co3O4 nanostructures. Moreover, EDS mapping analysis confirmed the existence of Co and O elements in the final structure, and the magnetic properties of the samples were investigated by VSM. The application of this nanostructure in a catalytic process was further examined, and the results suggested that it could be used as a novel candidate for the synthesis of arylidene barbituric and Meldrum(,)s acid through Knoevenagel condensation of aldehydes by barbituric and Meldrum(,)s acid in aqueous media. The high yield of these nanocatalysts would be justified by the nature of the nanostructure as well as the experimental procedure developed in this study, which affected the physicochemical features of the products.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Yahyazadehfar, M; Sheikhhosseini, E; Ahmadi, SA; Ghazanfari, D or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Welcome to talk about 100-83-4, If you have any questions, you can contact Jlassi, R; Khalladi, A; Naili, H; Ruffer, T; Lang, H; Rekik, W or send Email.. Product Details of 100-83-4

Authors Jlassi, R; Khalladi, A; Naili, H; Ruffer, T; Lang, H; Rekik, W in PERGAMON-ELSEVIER SCIENCE LTD published article about DOUBLE SULFATES; COMPLEXES; SPECTRA; NITRATE; LIGANDS; DESIGN; CU(II) in [Jlassi, Raja; Khalladi, Ahmed; Naili, Houcine; Rekik, Walid] Univ Sfax, Lab Physicochim Etat Solide, Dept Chim, Fac Sci Sfax, BP 1171, Sfax 3000, Tunisia; [Khalladi, Ahmed; Ruffer, Tobias; Lang, Heinrich] Tech Univ Chemnitz, Fak Nat Wissensch, Inst Chem, Anorgan Chem, D-09107 Chemnitz, Germany in 2019.0, Cited 40.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

The new complex [Zn(im)(4)](NO3)(2) (1) was synthesized and crystallographically characterized. In the solid state, 1 is built up by [Zn(C3H4N2)](2+) cations and NO3- anions interlinked by N-H center dot center dot center dot O hydrogen bonds which give rise to the formation of a 3D network. Complex 1 and [CdNa2(mu-L-2)](n)center dot 6.34H(2)O (2), (L=2-(2-(4,4-dimethyl-2,6-dioxocyclohexylidene) hydrazinyl)terephthalate) were used as catalysts for the Henry reaction, and high yields were obtained under optimum conditions. Both 1 and 2 act as very efficient catalysts for the Henry reaction and convert nitroethane and aldehydes to beta-nitroalcohols in yields of up to 89%. The threo/erythro diastereoselectivity depends on the choice of catalyst and also the selection of the reaction substrate, reaching values up to 89:11. (C) 2018 Elsevier Ltd. All rights reserved.

Welcome to talk about 100-83-4, If you have any questions, you can contact Jlassi, R; Khalladi, A; Naili, H; Ruffer, T; Lang, H; Rekik, W or send Email.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Tan, YJ; Ali, A; Tee, SY; Teo, JT; Xi, Y; Go, ML; Lam, YL or concate me.

An article Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells WOS:000496896600024 published article about FATTY-ACID SYNTHASE; EPIGALLOCATECHIN GALLATE; NATURAL INHIBITOR; OVEREXPRESSION; POLYPHENOLS; ACTIVATION; APOPTOSIS; PATHWAY; KINASE; GROWTH in [Tan, Yu-Jia; Tee, Sheng-Yang; Lam, Yulin] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore; [Tan, Yu-Jia; Teo, Jun -Ting] Yong Loo Lin Sch Med, Canc Sci Inst Singapore, 14 Med Dr, Singapore 117599, Singapore; [Xi, Yu; Go, Mei-Lin] Natl Univ Singapore, Dept Pharm, 18 Sci Dr 4, Singapore 117543, Singapore in 2019.0, Cited 55.0. Recommanded Product: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability. (C) 2019 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Tan, YJ; Ali, A; Tee, SY; Teo, JT; Xi, Y; Go, ML; Lam, YL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Welcome to talk about 100-83-4, If you have any questions, you can contact Alves, MA; de Queiroz, AC; Leite, AB; Martins, FT; Doriguetto, AC; Barreiro, EJ; Alexandre-Moreira, MS; Lima, LM or send Email.. Formula: C7H6O2

Formula: C7H6O2. I found the field of Chemistry very interesting. Saw the article Carbamoyl-N-aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate published in 2020.0, Reprint Addresses Lima, LM (corresponding author), Univ Fed Rio De Janeiro UFRJ, Lab Avaliacao & Sintese Subst Bioativas LASSBio, Inst Nacl Ciencia & Tecnol Farmacos & Medicamento, CCS, POB 68023, BR-21941902 Rio De Janeiro, RJ, Brazil.; Lima, LM (corresponding author), Univ Fed Rio de Janeiro, Inst Quim, Programa Posgrad Quim, BR-21941909 Rio de Janeiro, RJ, Brazil.; Alexandre-Moreira, MS (corresponding author), Univ Fed Alagoas UFAL, Inst Ciencias Biol & Sande, Lab Farmacol & Imunol, BR-57072900 Maceio, AL, Brazil.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

Leishmaniasis is a neglected parasitic disease, and current treatment includes limitations of toxicity, variable efficacy, high costs and inconvenient doses and treatment schedules. Therefore, new leishmanicidal drugs are still an unquestionable medical need. In this paper we described the design conception of a new framework, the carbamoyl-N-aryl-imine-urea, to obtain putative leishmanicidal drug-candidates. Compounds 9a-e and 10a-e were designed and synthesized and their leishmanicidal activity was studied in comparison to pentamidine, miltefosine and meglumine antimoniate. The conformational profile of the new carbamoyl-N-aryl-imine-urea framework was investigated by X-ray diffraction studies, using compound 9a as a model. The plasma stability of this putative peptide mimetic subunit was studied for compound 10e (LASSBio-1736). Among the congeneric series, LASSBio-1736 was identified as a new antileishmanial drug-candidate, displaying plasma stability, cytotoxicity against amastigote forms of L. amazonensis and L. braziliensis, and leishmanicidal activity in a cutaneous leishmaniasis murine model, without preliminary evidence of hepatic or renal toxicity.

Welcome to talk about 100-83-4, If you have any questions, you can contact Alves, MA; de Queiroz, AC; Leite, AB; Martins, FT; Doriguetto, AC; Barreiro, EJ; Alexandre-Moreira, MS; Lima, LM or send Email.. Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Safety of 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Bettencourt, AP; Castro, M; Silva, JP; Fernandes, F; Coutinho, OP; Sousa, MJ; Proenca, MF; Areias, FM or send Email.

Bettencourt, AP; Castro, M; Silva, JP; Fernandes, F; Coutinho, OP; Sousa, MJ; Proenca, MF; Areias, FM in [Bettencourt, Ana P.; Fernandes, Francisco; Proenca, Maria Fernanda; Areias, Filipe M.] Univ Minho, Dept Chem, Campus Gualtar, P-4710057 Braga, Portugal; [Castro, Marian] Univ Santiago de Compostela, BioFarma Res Grp, Ctr Res Mol Med & Chron Dis CiMUS, Ave Barcelona 22, Santiago De Compostela 15782, Spain; [Silva, Joao P.; Coutinho, Olga P.] Univ Minho, Dept Biol, Campus Gualtar, P-4710057 Braga, Portugal; [Sousa, Maria J.; Areias, Filipe M.] Univ Minho, CBMA Ctr Mol & Environm Biol, Dept Biol, Campus Gualtar, P-4710057 Braga, Portugal; [Areias, Filipe M.] Yachay Tech Univ, Sch Chem Sci & Engn, Yachay City Of Knowledge 100650, Urcuqui, Ecuador published Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship in 2019.0, Cited 33.0. Safety of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Background: Previous publications show that the addition of a phenolic antioxidant to an antifungal agent, considerably enhances the antifungal activity. Objective: Synthesis of novel compounds combining phenolic units with linear or cyclic nitrogencontaining organic molecules with antioxidant/antifungal activity using methodologies previously developed in the group. Methods: Several N- [1,2-dicyano-2- (arylidenamino) vinyl]-O-alkylformamidoximes 3 were synthesized and cyclized to 4,5-dicyano-N- (N’-alcoxyformimidoyl)-2-arylimidazoles 4 upon reflux in DMF, in the presence of manganese dioxide or to 6-cyano-8-arylpurines 5 when the reagent was refluxed in acetonitrile with an excess of triethylamine. These compounds were tested for their antioxidant activity by cyclic voltammetry, DPPH radical (DPPH.) assay and deoxyribose degradation assay. The minimum inhibitory concentration (MIC) of all compounds was evaluated against two yeast species, Saccharomyces cerevisiae and Candida albicans, and against bacteria Bacillus suhtill’s (Gram-positive) and Escherichia call (Gram negative). Their cytotoxicity was evaluated in fibroblasts. Results: Among the synthetised compounds, five presented higher antioxidant activity than reference antioxidant Trolox and from these compounds, four presented antifungal activity without toxic effects in fibroblasts and bacteria. Conclusion: Four novel compounds presented dual antioxidant/antifimgal activity at concentrations that are not toxic to bacteria and fibroblasts. The active molecules can be used as an inspiration for further studies in this area.

Safety of 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Bettencourt, AP; Castro, M; Silva, JP; Fernandes, F; Coutinho, OP; Sousa, MJ; Proenca, MF; Areias, FM or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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In 2020.0 EUR J ORG CHEM published article about ORGANOBORONIC ACIDS; MULTICOMPONENT REACTIONS; ARYLBORONIC ACIDS; BORONIC ESTERS; AMINES; SALICYLALDEHYDES; CYCLIZATION; INHIBITORS; DISCOVERY; ALDEHYDES in [Marques, Carolina S.; Burke, Anthony J.] Univ Evora, Inst Res & Adv Studies, Rua Romao Ramalho 59, P-7000671 Evora, Portugal; [McArdle, Patrick; Erxleben, Andrea] Natl Univ Ireland, Sch Chem, Galway, Ireland; [Burke, Anthony J.] Univ Evora, Dept Chem, Sch Sci & Technol, Rua Romao Ramalho 59, P-7000671 Evora, Portugal in 2020.0, Cited 67.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4

A one-step, three-component Petasis reaction of isatin derived 5-arylboronate-3-substituted oxindole derivatives with salicylaldehydes and secondary amines affords new enantiomerically pure structurally diverse 5-alpha-(3-substituted-oxindole)-benzylamine derivatives. The reaction shows good substrate and reagent scope affording the products with good to excellent yields (up to >99 % yield) and enantioselectivities (up to 99 % ee) using cheap and readily available (R)-BINOL as the organocatalyst. A diastereoselective version of the reaction was also developed where moderate yields (37 to 55 % yield), excellent enantioselectivities (up to 99 % ee) and good diastereoselectivities (up to 86 % de) were obtained for new 5-alpha-(3-hydroxy-oxindole)-benzylamine derivatives, having two stereocenters. The reaction is also feasible on gram-scale.

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Name: 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Selvaraj, B; Nguyen, UTT; Huh, G; Nguyen, DH; Mok, IK; Lee, H; Kang, K; Bae, AN; Kim, DW; Lee, JW or send Email.

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and biological evaluation of chalcone derivatives as neuroprotective agents against glutamate-induced HT22 mouse hippocampal neuronal cell death published in 2020.0. Name: 3-Hydroxybenzaldehyde, Reprint Addresses Lee, JW (corresponding author), Korea Inst Sci & Technol KIST, Nat Prod Res Ctr, 679 Saimdang Ro, Kangnung 25451, Gangwon Do, South Korea.; Lee, JW (corresponding author), Korea Inst Sci & Technol KIST, Convergent Res Ctr Diag Treatment & Care Syst Dem, Seoul 02792, South Korea.; Kim, DW (corresponding author), Gangneung Wonju Natl Univ GWNU, Coll Dent, Dept Biochem & Mol Biol, Kangnung 25457, South Korea.; Lee, JW (corresponding author), Univ Sci & Technol UST, Div Biomed Sci & Technol, Daejun 34113, South Korea.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Seventeen chalcone analogues were synthesized from 7-methoxy-3,4-dihydronaphthalen1(2H)-one and various aromatic aldehydes under basic conditions and their therapeutic properties were studied in mouse hippocampal cell line HT-22 against neuronal cell death induced by glutamate. From this study, we selected an analogue C01 as a active compound which showed significantly high neuroprotection. This compound inhibited Ca2+ influx and reactive oxygen species (ROS) accumulation inside cells. The glutamate-induced cell death was analyzed by flow cytometry and it showed that C01 significantly reduced apoptotic or dead cell induced by 5 mM glutamate. Western blot analysis indicates that glutamate-mediated activation of MAPKs were inhibited by compound C01 treatment. In addition, the C01enhanced Bcl-2 and decreased Bax, the anti and pro apoptotic proteins respectively. Further analysis showed that, C01 prevented the nuclear translocation of AIF (apoptosis inducing factor) and inhibited neuronal cell death. Taken together, compound C01 treatment resulted in decreased neurotoxicity induced by 5 mM of glutamate. Our finding confirmed that compound C01 has neuro-therapeutic potential against glutamate-mediated neurotoxicity.

Name: 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Selvaraj, B; Nguyen, UTT; Huh, G; Nguyen, DH; Mok, IK; Lee, H; Kang, K; Bae, AN; Kim, DW; Lee, JW or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles