Category: 100-83-4

Recommanded Product: 3-Hydroxybenzaldehyde. Recently I am researching about POLO-LIKE KINASE; CANCER, Saw an article supported by the China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019TQ0215]; Program of Liaoning Revitalization Talents Program [XLYC1808037]; Doctoral Scientific Research Foundation of Liaoning Province [2020-BS-130]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A series of novel pteridinone derivatives possessing a hydrazone moiety were designed, synthesized and evaluated for their biological activity. Most of the synthesized compounds demonstrated moderate to excellent activity against A549, HCT116 and PC-3 cancer cell lines. In particular, compound L-19 exhibited the most potent antiproliferative effects on three cell lines with IC50 values of 3.23 mu M, 4.36 mu M and 8.20 mu M, respectively. In kinase assays, the compound L-19 also showed potent inhibition activity toward PLK1 with % inhibition values of 75.1. Further mechanism studies revealed that compound L-19 significantly inhibited proliferation of HCT-116 cell lines, induced a great decrease in mitochondrial membrane potential resulting in apoptosis of cancer cells, inhibited the migration of tumor cells, and arrested G1 phase of HCT116 cells.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Magnetic BaFe12O19/Al2O3: An Efficient Heterogeneous Lewis Acid Catalyst for the Synthesis of alpha-Aminophosphonates (Kabachnik-Fields Reaction) WOS:000493659800014 published article about ONE-POT SYNTHESIS; 3-COMPONENT SYNTHESIS; AMINO PHOSPHONATES; MECHANISM; DERIVATIVES; INHIBITION in [Piri, Tayebeh; Peymanfar, Reza; Javanshir, Shahrzad; Amirnejat, Sara] Iran Univ Sci & Technol, Dept Chem, Heterocycl Chem Res Lab, Tehran 1684613114, Iran in 2019.0, Cited 35.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde

The design and application of environmentally friendly catalysts to reduce the quantity of toxic wastes is critical for improving the chemical synthesis process. Therefore, BaFe12O19/Al2O3, a magnetic mesoporous nanocomposites, were designed synthesized and characterized using different techniques such as energy dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller (BET) adsorption method, and vibrating sample magnetometry (VSM). The prepared BaFe12O19/Al2O3 display a high surface area (1773.22 m(2)/g) with an average pore diameter of 3.946 nm from nitrogen sorption analysis. In addition, the synthesized nanocomposites prove to be an active heterogeneous Lewis acid catalyst for the solvent free synthesis of alpha-aminophosphonates at ambient temperature, through three-component reaction of aldehydes/ketones, amines and triethyl phosphite. The use of this catalyst results in an effortless magnetic recoverability and recyclability, high yield and short reaction time under solvent-free conditions. Graphic

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Piri, T; Peymanfar, R; Javanshir, S; Amirnejat, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-83-4. Recently I am researching about ALPHA-FLUORINATED ETHERS; LASER FLASH-PHOTOLYSIS; TRANSITION-METAL-FREE; ELECTROCHEMICAL OXIDATION; PHOTOREDOX CATALYSIS; ALCOHOL OXIDATION; NITROXYL RADICALS; ELECTRON-TRANSFER; EFFICIENT; CHEMISTRY, Saw an article supported by the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R35GM119652]; NSFNational Science Foundation (NSF) [CHE-1827902, CHE-1654122, ACI-1053575]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Lee, JW; Lim, S; Maienshein, DN; Liu, P; Ngai, MY. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Applications of TEMPO(.)catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO.-catalyzed, redox-neutral C-H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO./TEMPO(+)redox catalytic cycle. Mechanistic studies also suggest that Li(2)CO(3)plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO(.)catalysis.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Lee, JW; Lim, S; Maienshein, DN; Liu, P; Ngai, MY or concate me.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Agriculture; Chemistry; Food Science & Technology very interesting. Saw the article Quantitative Dietary Fingerprinting (QDF) -A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics published in 2020.0. Recommanded Product: 3-Hydroxybenzaldehyde, Reprint Addresses Andres-Lacueva, C (corresponding author), Univ Barcelona, Biomarkers & Nutrimetabol Lab, Dept Nutr Food Sci & Gastron,Food Technol Referen, Nutr & Food Safety Res Inst INSA,Fac Pharm & Food, E-08028 Barcelona, Spain.; Andres-Lacueva, C (corresponding author), Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBER, Barcelona 08028, Spain.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Accurate dietary assessment is a challenge in nutritional research, needing powerful and robust tools for reliable measurement of food intake biomarkers. In this work, we have developed a novel quantitative dietary fingerprinting (QDF) approach, which enables for the first time the simultaneous quantitation of about 350 urinary food-derived metabolites, including (poly)phenolic aglycones, phase II metabolites, and microbial-transformed compounds, as well as other compounds (e.g., glucosinolates, amino acid derivatives, methylxanthines, alkaloids, and markers of alcohol and tobacco consumption). This method was fully validated for 220 metabolites, yielding good linearity, high sensitivity and precision, accurate recovery rates, and negligible matrix effects. Furthermore, 127 additional phase II metabolites were also included in this method after identification in urines collected from acute dietary interventions with various foods. Thus, this metabolomic approach represents one-step further toward precision nutrition and the objective of improving the accurateness and comprehensiveness in the assessment of dietary patterns and lifestyles.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Gonzalez-Dominguez, R; Urpi-Sarda, M; Jauregui, O; Needs, PW; Kroon, PA; Andres-Lacueva, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article ZnO nanostructures: a heterogeneous catalyst for the synthesis of benzoxanthene and pyranopyrazole scaffolds via a multi-component reaction strategy WOS:000613923500015 published article about ONE-POT SYNTHESIS; COMPONENT REACTIONS; DERIVATIVES; XANTHENE; ACID; NANOCRYSTALLINE; PHOTOCATALYST; ULTRAVIOLET; TRIFLATE; FILMS in [Chhattise, Prakash; Chabukswar, Vasant] SavitribaiPhule Pune Univ, NowrosjeeWadia Coll, Ness Wadia Nanomat Res Ctr, Dept Chem, Pune, Maharashtra, India; [Chhattise, Prakash; Pandit, Vikram] SavitribaiPhule Pune Univ, Haribhai V Desai Collge, Dept Chem, Pune 411002, Maharashtra, India; [Saleh, Suheb] Minist Educ, Outstanding Secondary Sch, Anbar, Iraq; [Arbuj, Sudhir] Ctr Mat Elect Technol, Mat Renewable Energy Div, Pashan Rd, Pune 411008, Maharashtra, India in 2020.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. COA of Formula: C7H6O2

A hydrothermal technique is employed for the preparation of nanostructured ZnO. The reaction was carried out at 180 degrees C for 2 h in the presence of ethylenediamine (EDA) as a capping agent and was characterized by X-ray diffraction (XRD), scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). XRD indicates the formation of highly crystalline ZnO having a wurtzite structure. FESEM analysis validates the formation of a submicron size spherical shaped marigold flower like morphology. The nanostructured ZnO was screened for its catalytic activity as a heterogeneous catalyst for the multicomponent synthesis of benzoxanthenes and pyranopyrazole derivatives in good to excellent yield. The major advantages associated with this methodology include ease of separation and reusability of the catalyst, easy work-up and short reaction time.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Chhattise, P; Saleh, S; Pandit, V; Arbuj, S; Chabukswar, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD in [Thi-Kim-Chi Huynh; Thi-Hong-An Nguyen; Thi-Cam-Thu Nguyen; Thi-Kim-Dung Hoang] Inst Chem Technol VAST, 01 Mac Dinh Chi Str,Dist 1, Ho Chi Minh City, Vietnam; [Thi-Kim-Chi Huynh; Thi-Kim-Dung Hoang] Grad Univ Sci & Technol VAST, 18 Hoang Quoc Viet Str, Hanoi, Vietnam; [Thi-Cam-Thu Nguyen] Ton Duc Thang Univ, 19 Nguyen Huu Tho Str,Dist 7, Ho Chi Minh City, Vietnam published Synthesis and insight into the structure-activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents in 2020.0, Cited 36.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained via a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their in vitro anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC50 values 4.47, 4.68 and 5.50 mu g mL(-1), respectively). In addition, compound 40 exhibited the best IC50 value of 3.55 mu g mL(-1) against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37-55 could improve their antiproliferative activities.

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H6O2. Smith, JB; Camp, AM; Farquhar, AH; Kerr, SH; Chen, CH; Miller, AJM in [Smith, Jacob B.; Camp, Andrew M.; Farquhar, Alexandra H.; Kerr, Stewart H.; Chen, Chun-Hsing; Miller, Alexander J. M.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA published Organometallic Elaboration as a Strategy for Tuning the Supramolecular Characteristics of Aza-Crown Ethers in 2019.0, Cited 58.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Outfitting an aza-crown ether with an organotransition-metal pendant provides a mechanism for tuning its supramolecular properties. The binding affinity can be tuned by more than 2 orders of magnitude by changing the identity of the transition metal-center, altering the overall charge of the complex, or engaging in organometallic ligand substitution reactions. High Li+ selectivity (up to 29-fold higher affinity in comparison to Na+), proton-responsive behavior, and ion pair (ditopic) binding capabilities are observed in the metallacrown ethers.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Smith, JB; Camp, AM; Farquhar, AH; Kerr, SH; Chen, CH; Miller, AJM or concate me.. HPLC of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 3-Hydroxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article Efficient atom-economic one-pot multicomponent synthesis of benzylpyrazolyl coumarins and novel pyrano[2,3-c]pyrazoles catalysed by 2-aminoethanesulfonic acid (taurine) as a bio-organic catalyst published in 2019.0, Reprint Addresses Chate, AV (corresponding author), Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

The present work describes eco-friendly multicomponent protocol for the synthesis in excellent yields of structurally diverse benzylpyrazolyl coumarin 5 (a-s) involving the reaction of 4-hydroxycoumarin, ethyl acetoacetate, hydrazine hydrate/phenyl hydrazine hydrate and aldehydes, also novel pyrano[2,3-c]pyrazole derivatives 8 (a-k) integrated by isonicotinic acid hydrazide from reaction of aldehyde, ethyl acetoacetate, malononitrile with isoniazid, employing water as a reaction medium and 2-aminoethanesulfonic acid (taurine) as the catalyst. This new methodology endowed the advantages such as short reaction time, recovery of catalysts after catalytic reaction and reusing them without losing their activity and alleviate of operation. [GRAPHICS] .

Name: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Chate, AV; Shaikh, BA; Bondle, GM; Sangle, SM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Accessing New 5-alpha-(3,3-Disubstituted Oxindole)-Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction WOS:000544049200011 published article about ORGANOBORONIC ACIDS; MULTICOMPONENT REACTIONS; ARYLBORONIC ACIDS; BORONIC ESTERS; AMINES; SALICYLALDEHYDES; CYCLIZATION; INHIBITORS; DISCOVERY; ALDEHYDES in [Marques, Carolina S.; Burke, Anthony J.] Univ Evora, Inst Res & Adv Studies, Rua Romao Ramalho 59, P-7000671 Evora, Portugal; [McArdle, Patrick; Erxleben, Andrea] Natl Univ Ireland, Sch Chem, Galway, Ireland; [Burke, Anthony J.] Univ Evora, Dept Chem, Sch Sci & Technol, Rua Romao Ramalho 59, P-7000671 Evora, Portugal in 2020.0, Cited 67.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A one-step, three-component Petasis reaction of isatin derived 5-arylboronate-3-substituted oxindole derivatives with salicylaldehydes and secondary amines affords new enantiomerically pure structurally diverse 5-alpha-(3-substituted-oxindole)-benzylamine derivatives. The reaction shows good substrate and reagent scope affording the products with good to excellent yields (up to >99 % yield) and enantioselectivities (up to 99 % ee) using cheap and readily available (R)-BINOL as the organocatalyst. A diastereoselective version of the reaction was also developed where moderate yields (37 to 55 % yield), excellent enantioselectivities (up to 99 % ee) and good diastereoselectivities (up to 86 % de) were obtained for new 5-alpha-(3-hydroxy-oxindole)-benzylamine derivatives, having two stereocenters. The reaction is also feasible on gram-scale.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Marques, CS; McArdle, P; Erxleben, A; Burke, AJ or concate me.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthetic Route of 100-83-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 100-83-4, Name is 3-Hydroxybenzaldehyde, SMILES is O=CC1=CC=CC(O)=C1, belongs to indole-building-block compound. In a article, author is Haefner, Maximilian, introduce new discover of the category.

An enantioselective synthesis of functionalized cyclohepta[b]indoles via Pd-catalyzed cyclopropane C-H activation followed by olefination and indole-vinylcyclopropane rearrangement is reported. The design of the chiral cyclopropane precursor was such that both enantiomeric cyclohepta[b]indoles were accessed from a single compound exhibiting a hidden symmetry plane. The scope of the method was demonstrated by varying the substituents on the cyclopropane as well as on the heterocycle itself.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles