Category: 100-83-4

Authors You, SY; Zhang, RL; Cai, MZ in GEORG THIEME VERLAG KG published article about NANOPARTICLES-SUPPORTED PALLADIUM; REDUCTIVE CARBONYLATION; COUPLING REACTIONS; N-FORMYLSACCHARIN; REUSABLE CATALYST; HIGHLY EFFICIENT; HALIDES; SUZUKI; PD; SONOGASHIRA in [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong] Jiangxi Acad Sci, Inst Appl Chem, Nanchang 330029, Jiangxi, Peoples R China in 2021, Cited 68. Recommanded Product: 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A magnetically recyclable palladium-catalyzed formylation of aryl iodides under CO gas-free conditions has been developed by using a bidentate phosphine ligand-modified magnetic nanoparticles-anchored- palladium(II) complex [2P-Fe3O4@SiO2-Pd(OAc)(2)] as catalyst, yielding a wide variety of aromatic aldehydes in moderate to excellent yields. Here, formic acid was employed as both the CO source and the hydrogen donor with iodine and PPh3 as the activators. This immobilized palladium catalyst can be obtained via a simple preparative procedure and can be facilely recovered simply by using an external magnetic field, and reused at least 9 times without any apparent loss of catalytic activity.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact You, SY; Zhang, RL; Cai, MZ or concate me.. Recommanded Product: 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 DALTON T published article about ASYMMETRIC TRANSFER HYDROGENATION; ENANTIOSELECTIVE TRANSFER HYDROGENATION; NICKEL-COMPLEXES; IRON CATALYSTS; COBALT; RUTHENIUM; REDUCTION; EFFICIENT; LIGANDS; BONDS in [Segizbayev, Medet; Oztopcu, Ozgur; Hayrapetyan, Davit; Shakhman, Dinmukhamed; Khalimon, Andrey Y.] Nazarbayev Univ, Sch Sci & Humanities, Dept Chem, 53 Kabanbay Batyr Ave, Nur Sultan 010000, Kazakhstan; [Lyssenko, Konstantin A.] Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119991, Russia; [Lyssenko, Konstantin A.] Plekhanov Russian Univ Econ, Stremyanny 36, Moscow 117997, Russia; [Khalimon, Andrey Y.] Nazarbayev Univ, Environm & Resource Efficiency Cluster EREC, 53 Kabanbay Batyr Ave, Nur Sultan 010000, Kazakhstan in 2020.0, Cited 47.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Quality Control of 3-Hydroxybenzaldehyde

The aminophosphinite pincer complex (POCNH)NiBr was found to effectively catalyze the transfer hydrogenation of aldehydes and ketones with 2-propanol and (KOBu)-Bu-t as a base, presenting a rare example of bifunctional nickel transfer hydrogenation catalysts. The transfer hydrogenation of aldehydes and ketones was found to be selective, tolerating a wide range of other functional groups, including those prone to reduction, such as esters, amides, alkenes, pyridines, and nitriles. The reactions were suggested to proceed via the metal-ligand cooperative mechanism with an intermediacy of an amido (POCN)Ni-II species.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Segizbayev, M; Oztopcu, O; Hayrapetyan, D; Shakhman, D; Lyssenko, KA; Khalimon, AY or concate me.. Quality Control of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about DEMETHYLASE 1 LSD1; ANTITUMOR-ACTIVITY; HISTONE; ANTIOXIDANT, Saw an article supported by the . Name: 3-Hydroxybenzaldehyde. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Wang, JM; Zhang, XY; Yan, JK; Li, W; Jiang, QW; Wang, XR; Zhao, DM; Cheng, MS. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Histone lysine-specific demethylase 1 (LSD1) was the first discovered histone demethylase. Inactivating LSD1 or downregulating its expression inhibits cancer-cell development, and thus, it is an attractive molecular target for the development of novel cancer therapeutics. In this study, we worked on the structural optimization of natural products and identified 30 novel LSD1 inhibitors. Utilizing a structure-based drug design strategy, we designed and synthesized a series of curcumin analogues that were shown to be potent LSD1 inhibitors in the enzyme assay. Compound WB07 displayed the most potent LSD1 inhibitory activity, with an IC50 value of 0.8 mu M. Moreover, WA20 showed an anticlonogenic effect on A549 cells with an IC50 value of 4.4 mu M. Molecular docking simulations were also carried out, and the results indicated that the inhibitors bound to the protein active site located around the key residues of Asp555 and Asp556. These findings suggested that compounds WA20 and WB07 are the first curcumin analogue-based LSD1 inhibitors with remarkable A549 suppressive activity, providing a novel scaffold for the development of LSD1 inhibitors.

Name: 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 100-83-4. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors published in 2020.0, Reprint Addresses Liu, YJ; Hou, YL (corresponding author), Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

A series of novel pteridinone derivatives possessing a hydrazone moiety were designed, synthesized and evaluated for their biological activity. Most of the synthesized compounds demonstrated moderate to excellent activity against A549, HCT116 and PC-3 cancer cell lines. In particular, compound L-19 exhibited the most potent antiproliferative effects on three cell lines with IC50 values of 3.23 mu M, 4.36 mu M and 8.20 mu M, respectively. In kinase assays, the compound L-19 also showed potent inhibition activity toward PLK1 with % inhibition values of 75.1. Further mechanism studies revealed that compound L-19 significantly inhibited proliferation of HCT-116 cell lines, induced a great decrease in mitochondrial membrane potential resulting in apoptosis of cancer cells, inhibited the migration of tumor cells, and arrested G1 phase of HCT116 cells.

Recommanded Product: 100-83-4. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article C3 amino-substituted chalcone derivative with selective adenosine rA(1) receptor affinity in the micromolar range WOS:000590271200001 published article about ALPHA-KETO ACIDS; DRUG DISCOVERY; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL-ACTIVITIES; INTERNATIONAL UNION; SCREENING LIBRARIES; ANTAGONIST; INHIBITORS; BRAIN; BINDING in [Janse van Rensburg, Helena D.; Legoabe, Lesetja J.; Terre’Blanche, Gisella] North West Univ, Ctr Excellence Pharmaceut Sci, Private Bag X6001, ZA-2520 Potchefstroom, South Africa; [Terre’Blanche, Gisella] Northwest Univ, Sch Pharm, Pharmaceut Chem, Private Bag X6001, ZA-2520 Potchefstroom, South Africa in 2021.0, Cited 124.0. Quality Control of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15-36 and 37-41) and structurally related compounds (42-47) are reported. These compounds were characterized by radioligand binding and GTP shift assays to determine the degree and type of binding affinity, respectively, against rat (r) A(1) and A(2A) ARs. The chalcone derivatives 24, 29, 37 and 38 possessed selective A(1) affinity below 10 mu M, and thus, are the most active compounds of the present series; compound 38 was the most potent selective A(1) AR antagonist (K-i (r) = 1.6 mu M). The structure-affinity relationships (SAR) revealed that the NH2-group at position C3 of ring A of the chalcone scaffold played a key role in affinity, and also, the Br-atom at position C3 ‘ on benzylidene ring B. Upon in vitro and in silico evaluation, the novel C3 amino-substituted chalcone derivative 38-that contains an alpha,ss-unsaturated carbonyl system and easily allows structural modification-may possibly be a synthon in future drug discovery. [GRAPHICS] .

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact van Rensburg, HDJ; Legoabe, LJ; Terre’Blanche, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Ultrasound assisted synthesis of tetrazole based pyrazolines and isoxazolines as potent anticancer agents via inhibition of tubulin polymerization WOS:000594729200014 published article about BIOLOGICAL EVALUATION; COMBRETASTATIN A-4; DERIVATIVES; ANALOGS; DESIGN; ANTIBACTERIAL; ANTITUMOR; HYBRIDS; GROWTH; APOPTOSIS in [Dofe, Vidya S.] Deogiri Coll, Dept Chem, Aurangabad 431005, Maharashtra, India; [Sarkate, Aniket P.; Karnik, Kshipra S.; Kale, Ishwari A.] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India; [Tiwari, Shailee, V] Durgamata Inst Pharm, Dept Pharmaceut Chem, Parbhani 431401, Maharashtra, India; [Lokwani, Deepak K.] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur 425405, MS, India; [Dodamani, Suneel; Jalalpure, Sunil S.] KLE Acad Higher Educ & Res, Dr Prabhakar Kore Basic Sci Res Ctr, Belagavi 590010, Karnataka, India; [Jalalpure, Sunil S.] KLE Acad Higher Educ & Res, KLE Coll Pharm, Belagavi 590010, Karnataka, India; [Burra, Prasad V. L. S.] KLEF Univ, Dept Biotechnol, Vaddeswaram 522502, AP, India in 2020.0, Cited 49.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Product Details of 100-83-4

In search of new active molecules against MCF-7, A549 and HepG2, tetrazole based pyrazoline and isoxazoline derivatives under both conventional and ultrasonic irradiation method were designed and efficiently synthesized. Structures of newly synthesized compounds 5a-h and 6a-h were characterized by H-1 NMR, C-13 NMR, MS and elemental analysis. Several derivatives were found to be excellent cytotoxic against MCF-7, A549 and HepG2 cell lines characterized by lower IC50 values (0.78-3.12 mu g/mL). Compounds 5b and 5c demonstrated an antiproliferative effect comparable to that of CA-4. Western blot analysis revealed that, reported compounds accumulate more tubulin in the soluble fraction. Docking studies suggested that, binding of these compounds mimics at the colchicine site of tubulin. In vitro study revealed that the tetrazole based pyrazolines and isoxazolines may possess ideal structural requirements for further development of novel therapeutic agents.

Product Details of 100-83-4. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Synthesis and characterization of Mannich bases of lawsone and their anticancer activity published in 2020.0. HPLC of Formula: C7H6O2, Reprint Addresses Thakore, S (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Natural and synthetic naphthoquinones are known for a large number of biological activities. Lawsone (2-hydroxy-1, 4-naphthoquinone) is a simplest naturally occurring compound obtained from dried henna (Lawsonia inermis) leaves. In literature, some lawsone derivatives have been reported to exhibit anticancer activity. Hence, a clean and facile one-pot protocol was developed for the synthesis of new aminonaphthoquinones derived from lawsone by three-component Mannich reaction, at room temperature for potential anti-cancer application. Herein we present a small library of Mannich bases with different amines and aromatic aldehydes with moderate to high yield. Synthesized compounds were characterized using various spectroscopic techniques. The anticancer activity (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay) along with nuclear morphology assessment (4 ‘,6-diamidino-2-phenylindole or DAPI staining), apoptosis assessment (acridine orange/ ethidium bromide staining), hemolysis and DNA ladder assay evaluated on human liver carcinoma cell line HepG2 are presented.

HPLC of Formula: C7H6O2. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-83-4. In 2019.0 BIOORG CHEM published article about COLCHICINE BINDING-SITE; BIOLOGICAL EVALUATION; COMBRETASTATIN A-4; TUBULIN; INHIBITORS; CHEMOTHERAPY; DERIVATIVES; DESIGN; SERIES in [Zhang, Ya-Liang; Yang, Rong; Xia, Lin-Ying; Man, Ruo-Jun; Chu, Yi-Chun; Wang, Zhong-Chang; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China; [Jiang, Ai-Qin] Nanjing Univ, Med Sch, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 29.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI(50) = 0.71-2.41 mu M against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 mu M against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 mu M). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

SDS of cas: 100-83-4. Welcome to talk about 100-83-4, If you have any questions, you can contact Zhang, YL; Yang, R; Xia, LY; Man, RJ; Chu, YC; Jiang, AQ; Wang, ZC; Zhu, HL or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H6O2. In 2020.0 CHEMISTRYSELECT published article about ONE-POT SYNTHESIS; 3-COMPONENT SYNTHESIS; ENERGY-EFFICIENT; ISOXAZOLE; DERIVATIVES; CHEMISTRY; OXIDATION; CATALYST; PROTOCOL; DYES in [Gadkari, Yatin U.; Telvekar, Vikas N.] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Mumbai 400019, Maharashtra, India; [Jadhav, Nilesh L.] Inst Chem Technol, Dept Chem Engn, Mumbai 400019, Maharashtra, India; [Hatvate, Navnath T.] St John Inst Pharm & Res, Dept Pharmaceut Chem, Palghat 401404, India in 2020.0, Cited 49.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

An efficient, clean, and environmentally benign approach for the synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones has been developed using concentrated solar radiations (CSR). One pot, multicomponent synthesis from aromatic / heteroaromatic aldehydes, ethyl acetoacetate and hydroxylamine hydrochloride leads to title compounds in high yields. Notably the reaction has been carried out in under solvent and catalyst-free conditions within a very short time (3 min). Further, the reaction was scaled up to 50 mmol. The present method is also energy efficient and saves almost more than 87 % of energy as compared to the conventional method.

COA of Formula: C7H6O2. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Leong, SW; Awin, T; Faudzi, SMM; Maulidiani, M; Shaari, K; Abas, F in [Leong, Sze Wei; Awin, Tahani; Faudzi, Siti Munirah Mohd; Shaari, Khozirah; Abas, Faridah] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia; [Leong, Sze Wei] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Microbiol, Serdang 43400, Selangor, Malaysia; [Awin, Tahani] Univ Benghazi, Fac Sci, Dept Chem, Benghazi, Libya; [Faudzi, Siti Munirah Mohd; Shaari, Khozirah] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia; [Maulidiani, M.] Univ Malaysia Terengganu, Sch Fundamental Sci, Kuala Nerus 21030, Terengganu, Malaysia; [Abas, Faridah] Univ Putra Malaysia, Dept Food Sci, Fac Food Sci & Technol, Serdang 43400, Selangor, Malaysia published Synthesis and biological evaluation of asymmetrical diarylpentanoids as antiinflammatory, anti-alpha-glucosidase, and antioxidant agents in 2019.0, Cited 26.0. Computed Properties of C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A series of seven new (1, 3, 6, 7, 10, 12, and 13) and six (2, 4, 5, 8, 9, and 11) known diarylpentanoid analogs were synthesized and assessed for their nitric oxide (NO) and alpha-glucosidase inhibitory activities as well as their antioxidant capacity. Nine compounds (2, 3, 4, 5, 6, 8, 11, 12, and 13) were found to exhibit comparable activity to that of curcumin (IC50 = 13.0 mu M), in which compound 8 has displayed strongest NO inhibitory activity with the IC50 values of 17.5 mu M. Meanwhile, four compounds (1, 7, 12, and 13) were found to possess better alpha-glucosidase inhibitory activity than that of curcumin (30.9 mu M), with the IC50 values ranging from 19.4 to 24.9 mu M. On the other hand, none of the synthesized compounds has achieved better DPPH scavenging activities than that of curcumin, indicating the relatively poor antioxidant potential of desired diarylpentanoid structure. Structure-activity relationship (SAR) study disclosed that the existence of meta-hydroxyphenyl and bromo groups is crucial for antiinflammatory and anti-alpha-glucosidase activities, respectively. Molecular docking study showed that bromo moiety could form additional hydrophobic contacts with alpha-glucosidase, thereby increased the inhibition of diarylpentanoid against alpha-glucosidase. The overall results suggested that diarylpentanoids with poly-meta-hydroxylated phenyl ring and multiple bromo groups may lead to the discovery of new diarylpentanoids with both antiinflammatory and anti-alpha-glucosidase activities.

Computed Properties of C7H6O2. Welcome to talk about 100-83-4, If you have any questions, you can contact Leong, SW; Awin, T; Faudzi, SMM; Maulidiani, M; Shaari, K; Abas, F or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles