With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1000340-34-0,4-Bromo-3-iodo-7-azaindole,as a common compound, the synthetic route is as follows.,1000340-34-0
Method A:Sodium hydride (2.403 g, 60.1 mmol) was added portionwise to a cooled mixture 4- bromo-3-iodo-lH-pyrrolo[2,3-b]pyridine (D6) (13.86 g, 42.9 mmol) in DMF (200 mL) at 0 C and was stirred at that temperature for 15 min. 2-iodopropane (5.15 ml, 51.5 mmol) was then added and the reaction mixture was allowed to warm to RT and stirred overnight. The reaction mixture was cooled to 0 C again and quenched with saturated NH4C1 solution (ca. 5 mL) and further diluted with water (ca. 200 mL). The aqueous layer was extracted with ethyl acetate (3 x 200 mL). The organic layer was dried and concentrated down. The residue was purified on silica, eluting with ethyl acetate in cyclohexane (0-10%) to give the title compound (14 g). LCMS (A): m/z (M+H)+ 365/367, C10H10BrIN2 requires 364/366 (acidic).
The synthetic route of 1000340-34-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO WELLCOME MANUFACTURING PTE LTD; CHEN, Deborah, W.; DUNCAN, Sarah; KING, Nigel, Paul; LEE, Kiew, Ching; MAK, Sing, Yeung; RIVERS, Dean, Andrews; WO2012/170752; (2012); A1;,
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