Category: 1008-89-5

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Selective Halogenation of Pyridines Using Designed Phosphine Reagents, the main research direction is regioselective halogenation pyridine phosphine phosphonium salt mol modeling; halopyridine preparation.Name: 2-Phenylpyridine.

Halopyridines are key building blocks for synthesizing pharmaceuticals, agrochems., and ligands for metal complexes, but strategies to selectively halogenate pyridine C-H precursors are lacking. We designed a set of heterocyclic phosphines that are installed at the 4-position of pyridines as phosphonium salts and then displaced with halide nucleophiles. A broad range of unactivated pyridines can be halogenated, and the method is viable for late-stage halogenation of complex pharmaceuticals. Computational studies indicate that C-halogen bond formation occurs via an SNAr pathway, and phosphine elimination is the rate-determining step. Steric interactions during C-P bond cleavage account for differences in reactivity between 2- and 3-substituted pyridines.

Although many compounds look similar to this compound(1008-89-5)Name: 2-Phenylpyridine, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dayanidhi, P. David; Vaidyanathan, V. G. published an article about the compound: 2-Phenylpyridine( cas:1008-89-5,SMILESS:C1(C2=CC=CC=C2)=NC=CC=C1 ).Recommanded Product: 1008-89-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1008-89-5) through the article.

Mutagenic agents such as aromatic amines undergo metabolic activation and produce DNA adducts at C8 position of guanine bases. N-2-acetylaminofluorene (AAF) generates different mutational outcomes when placed at G1, G2, and G3 of a NarI sequence (-G1G2CG3CC/T-). These outcomes are dictated by the conformations adopted by these adducts. Detection of such lesions is of considerable interest owing to their hazardous effects. Here, we report the synthesis of three cyclometalated [Ir(L)2dppz]+ complexes (L = 2-phenylpyridine (ppy) 1; benzo[h]quinoline (bhq) 2; 2-phenylquinoline (pq) 3; dppz = dipyrido[3,2-a:2,3-c]phenazine) and their interaction with AAF adducted NarI DNA. Remarkably, complexes 1 and 2 displayed dominant 3LC transition characteristic of polar environment despite binding to the adducted sites. On the other hand, complex 3 binds to NarI sequences and behaves as a luminescent reporter for AAF-modified DNA. The results reported here emphasize that mol. light switching phenomenon can be stimulated by switching ancillary ligands and might act as potential probes for covalent-DNA defects.

Although many compounds look similar to this compound(1008-89-5)Recommanded Product: 1008-89-5, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Rigid Bridge-Confined Double-Decker Platinum(II) Complexes Towards High-Performance Red and Near-Infrared Electroluminescence, the main research direction is platinum double decker bridge confined red near IR electroluminescence; NIR emission; OLEDs; metallophilicity; platinum complexes; red emission.Related Products of 1008-89-5.

A mol. design to high-performance red and near-IR (NIR) organic light-emitting diodes (OLEDs) emitters remains demanding. Herein dinuclear Pt(II) complexes featuring strong intramol. Pt···Pt and π-π interactions were developed by using N-deprotonated α-carboline as a bridging ligand. The complexes in doped thin films exhibit efficient red to NIR emission from short-lived (τ = 0.9-2.1 μs) triplet metal-metal-to-ligand charge transfer (3MMLCT) excited states. Red OLEDs demonstrate high maximum external quantum efficiencies (EQEs) of ≤23.3% among the best PtII-complex-doped devices. The maximum EQE of 15.0% and radiance of 285 W sr-1 m-2 for NIR OLEDs (λEL = 725 nm) are unprecedented for devices based on discrete mol. emitters. Both red and NIR devices show very small efficiency roll-off at high brightness. Appealing operational lifetimes also were revealed for the devices. This work sheds light on the potential of intramol. metallophilicity for long-wavelength mol. emitters and electroluminescence.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms》. Authors are Rammal, Fatima; Gao, Di; Boujnah, Sondes; Hussein, Aqeel A.; Lalevee, Jacques; Gaumont, Annie-Claude; Morlet-Savary, Fabrice; Lakhdar, Sami.The article about the compound:2-Phenylpyridinecas:1008-89-5,SMILESS:C1(C2=CC=CC=C2)=NC=CC=C1).Recommanded Product: 2-Phenylpyridine. Through the article, more information about this compound (cas:1008-89-5) is conveyed.

Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation The synthetic importance of the developed reactions is demonstrated by the synthesis of biol. relevant compounds ESR spectroscopy, quantum yield measurements, and d.-functional theory calculations allowed to understand reaction mechanisms of both photocatalytic reactions.

Compounds in my other articles are similar to this one(2-Phenylpyridine)Recommanded Product: 2-Phenylpyridine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 2-Phenylpyridine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes. Author is Jeon, Jinwon; He, Yu-Tao; Shin, Sanghoon; Hong, Sungwoo.

The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process was initiated by the selective addition of a CF3 radical to the alkene moiety of N-(alkenyloxy)pyridinium salts I [X = O, Z = (CH2)3, R1 = H, 2-Me, 3-MeO2C, 4-Ph, etc., R2 = H, Me; X = O, Z = CH2, CH2CH2, (CH2)4, R1 = 4-MeO2C, R2 = H; X = NTs, Z = CH2, CH2CH2, R1 = H, 4-MeO2C, R2 = H; etc.] to provide a nucleophilic alkyl radical intermediate, which enabled an intramol. endo addition exclusively to the ortho-position of the pyridinium salt to afford the corresponding functionalized pyridines II. Both secondary and tertiary alkyl radicals were well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive mols.

Compounds in my other articles are similar to this one(2-Phenylpyridine)Name: 2-Phenylpyridine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts, the main research direction is bis heteroaryl preparation; halopyridine pyridylsulfonium salt coupling reaction.COA of Formula: C11H9N.

Herein ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts I (R = H, Br, Me, trifluoromethyl; R1 = H, OMe, CN, Br, etc.; R2 = H, trifluoromethyl; R3 = H, Me; R2R3 = -(CH=CH-CH=CH)-) and phenyl(pyrimidin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate are reported. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages including 2,4′-bipyridines, 2,3′-bipyridines, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes II (R4 = 2-fluoropyridin-4-yl, pyrazin-2-yl, dimethyl-1,2-oxazol-4-yl, 1-benzothiophen-2-yl, etc.). The methodol. was successfully applied to the synthesis of the natural products caerulomycin A and E.

In some applications, this compound(1008-89-5)COA of Formula: C11H9N is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Desulfonative Suzuki-Miyaura Coupling of Sulfonyl Fluorides, the main research direction is sulfonyl fluoride desulfonative Suzuki Miyaura coupling palladium; SuFEx; cross-coupling; heterocycles; palladium; reaction mechanisms.COA of Formula: C11H9N.

Sulfonyl fluorides have emerged as powerful “”click”” electrophiles to access sulfonylated derivatives Yet, they are relatively inert towards C-C bond forming transformations, notably under transition-metal catalysis. Here, authors describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki-Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogs of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S-Nu and C-C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C-S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.

In some applications, this compound(1008-89-5)COA of Formula: C11H9N is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Rational Design of Near-Infrared-Absorbing Pt(II)-Chelated Azadipyrromethene Dyes as a New Generation of Photosensitizers for Synergistic Phototherapy, published in 2020-12-21, which mentions a compound: 1008-89-5, mainly applied to platinum azadipyrromethene dye preparation cancer photothermal photodynamic photosensitizer, Formula: C11H9N.

Pt(II) photosensitizers are emerging as novel Pt anticancer agents for cancer photodynamic therapy (PDT) to avoid uncontrollable toxicity of cisplatin. However, the application of Pt(II) photosensitizers is limited by tumor hypoxia and the poor penetration depth of excitation light. To overcome these drawbacks, exploiting the next generation of Pt anticancer agents is of urgent need. According to theor. calculations, novel near-IR (NIR)-absorbing Pt(II)-chelated azadipyrromethene dyes (PtDP-X, where X = N, C, and S) were designed. Importantly, spin-orbit coupling of the Pt atom could promote the intersystem crossing of a singlet-to-triplet transition for converting oxygen to singlet oxygen (1O2), and the azadipyrromethene skeleton could provide a strong photothermal effect. As expected, PtDP-X exhibited intense NIR absorption and synergistic PDT and photothermal effects with low dark cytotoxicity. Furthermore, water-soluble and biocompatible PtDP-N nanoparticles (PtDP-N NPs) were prepared that achieved effective tumor cell elimination with low side effects under 730 nm light irradiation in vitro and in vivo. This pioneering work could push the exploitation of NIR-absorbing metal-chelated azadipyrromethene dyes, so as to promote the pos. evolution of phototherapy agents. A novel series of near-IR (NIR)-absorbing Pt(II)-chelated azadipyrromethene dyes (PtDP-X, where X = N, C, and S) are developed as a new generation of Pt(II)-based anticancer agents through a facile and feasible approach. Upon NIR light irradiation, PtDP-X possesses excellent synergistic photodynamic (PDT) and photothermal (PTT) therapeutic effects in vitro and in vivo.

In some applications, this compound(1008-89-5)Formula: C11H9N is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Phosphorescent Ir (III) complexes as cellular staining agents for biomedical molecular imaging, published in 2020-08-01, which mentions a compound: 1008-89-5, Name is 2-Phenylpyridine, Molecular C11H9N, SDS of cas: 1008-89-5.

A review. Phosphorescent Ir(III) complexes have attracted abundant attention in biomedical research due to their wide ranging properties and organelle specific intracellular imaging. Various types of Ir (III) complexes have been synthesized for visualization and monitoring of subcellular organelles and diagnosis of cancer. The aim of this review is to evaluate the progress of the phosphorescent Ir(III) complexes in bioimaging applications. We intend to highlight the use of Ir(III) complexes for staining the subcellular organelles, providing phosphorescence lifetime imaging microscopy, two photon and hypoxic tumor bioimaging.

As far as I know, this compound(1008-89-5)SDS of cas: 1008-89-5 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhou, Enmu; Jin, Jianzhong; Zheng, Kai; Zhang, Letian; Xu, Hao; Shen, Chao researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Recommanded Product: 1008-89-5.They published the article 《Novel Recyclable Pd/H-MOR Catalyst for Suzuki-Miyaura Coupling and Application in the Synthesis of Crizotinib》 about this compound( cas:1008-89-5 ) in Catalysts. Keywords: zeolite support palladium nanocatalyst preparation surface area green chem; haloarene phenyl boronic acid palladium nanocatalyst Suzuki Miyaura coupling; phenyl arene preparation. We’ll tell you more about this compound (cas:1008-89-5).

In this paper, an effective ultrasound method for the synthesis of Pd/H-MOR, which was used as a catalyst in the Suzuki-Miyaura coupling of aryl halides with phenylboronic acids was reported. The structure and morphol. of the as-prepared catalysts were fully characterized by X-ray diffraction (XRD), N2 sorption isotherms, SEM (SEM) and an inductively coupled plasma-at. emission spectrometer (ICP-AES). The advantages of Pd/H-MOR in the coupling reaction are green solvents, high yields, absence of ligands and recyclability. The catalysts were easily reused at least ten times without significant deterioration in catalytic activity. In addition, this protocol was used in the marketed anti-tumor drug crizotinib synthesis.

As far as I know, this compound(1008-89-5)Recommanded Product: 1008-89-5 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles