Category: 1008-89-5

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chen, Shu-Jie; Chen, Guo-Shu; Deng, Tao; Li, Jia-Hui; He, Zhi-Qing; Liu, Li-Shan; Ren, Hai; Liu, Yun-Lin researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Product Details of 1008-89-5.They published the article 《1,2-Dicarbofunctionalization of Trifluoromethyl Alkenes with Pyridinium Salts via a Cycloaddition/Visible-Light-Enabled Fragmentation Cascade》 about this compound( cas:1008-89-5 ) in Organic Letters. Keywords: pyridine preparation cycloaddition; trifluoromethyl alkene pyridinium salt preparation. We’ll tell you more about this compound (cas:1008-89-5).

Although trifluoromethyl alkenes have great synthetic potential, their 1,2-difunctionalization has been a challenge. In this Letter, authors disclose the first 1,2-dicarbofunctionalization of trifluoromethyl alkenes with pyridinium salts via a cascade process involving a base-promoted [3+2] cycloaddition followed by a visible-light-mediated Norrish-type-II fragmentation. This protocol allows for the formation of pyridines bearing a trifluoromethyl-substituted quaternary center in moderate to excellent yields under mild conditions.

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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 2-Phenylpyridine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Highly Chemoselective Deoxygenation Of N-Heterocyclic N-Oxides Using Hantzsch Esters As Mild Reducing Agents. Author is An, Ju Hyeon; Kim, Kyu Dong; Lee, Jun Hee.

A highly chemoselective room-temperature deoxygenation method applicable to various functionalized N-heterocyclic N-oxides via visible light-mediated metallaphotoredox catalysis using Hantzsch esters as the sole stoichiometric reductant to afford deoxygenated N-heterocycles I [R = 6-OMe, 6-Cl, 2-Ph, etc.], II [R1 = H, 5-Br; X = CH, N] and III [R2 = 3-Ph, 2,6-Cl2, pyridin-2-yl, etc.] were reported. Despite the feasibility of catalyst-free conditions, most of these deoxygenations could be completed within a few minutes using only a tiny amount of a catalyst. This technol. also allowed for multigram-scale reactions even with an extremely low catalyst loading of 0.01 mol %. The scope of this scalable and operationally convenient protocol encompassed a wide range of functional groups, such as amides, carbamates, esters, ketones, nitrile groups, nitro groups and halogens, which provided access to the corresponding compounds I, II and III in good to excellent yields (an average of an 86.8% yield for a total of 45 examples).

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts, Author is Che, Yuan-Yuan; Yue, Yanni; Lin, Ling-Zhi; Pei, Bingbing; Deng, Xuezu; Feng, Chao, which mentions a compound: 1008-89-5, SMILESS is C1(C2=CC=CC=C2)=NC=CC=C1, Molecular C11H9N, Safety of 2-Phenylpyridine.

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1008-89-5, is researched, SMILESS is C1(C2=CC=CC=C2)=NC=CC=C1, Molecular C11H9NJournal, Article, Chemistry – A European Journal called Rhoda-Electrocatalyzed C-H Methylation and Paired Electrocatalyzed C-H Ethylation and Propylation, Author is Kucinski, Krzysztof; Simon, Hendrik; Ackermann, Lutz, the main research direction is nitroheteroarene potassium alkyltrifluoroborate rhodium electrocatalyst regioselective alkylation green chem; alkyl nitroheteroarene preparation; C−H activation; electrochemistry; methylation; paired electrolysis; rhodium.Product Details of 1008-89-5.

Herein, the rhoda-electrocatalyzed C-H activation/alkylation of several N-heteroarenes was described. This catalytic approach was successfully applied to several arenes, including biol. relevant purines, diazepam, and amino acids. The versatile C-H alkylation featured water as a co-solvent and user-friendly trifluoroborates as alkylating agents. Finally, the rhoda-electrocatalysis with unsaturated organotrifluoroborates proceeded by paired electrolysis.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 2-Phenylpyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Photo-Induced Ruthenium-Catalyzed C-H Benzylations and Allylations at Room Temperature. Author is Struwe, Julia; Korvorapun, Korkit; Zangarelli, Agnese; Ackermann, Lutz.

The ruthenium-catalyzed synthesis of diarylmethane compounds was realized under exceedingly mild photoredox conditions without the use of exogenous photocatalysts. The versatility and robustness of the ruthenium-catalyzed C-H benzylation was reflected by an ample scope, including multifold C-H functionalizations, as well as transformable pyrazoles, imidates and sensitive nucleosides. Mechanistic studies were indicative of a photoactive cyclometalated ruthenium complex, which also enabled versatile C-H allylations.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Li, Wentao; Miao, Tiezheng; Wang, Baowen; Liu, Jiaxiang; Lu, Xingqiang; Fu, Guorui; Feng, Weixu; Wong, Wai-Yeung researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Recommanded Product: 1008-89-5.They published the article 《C1-Symmetric [Ir(C^N1)(C^N2)(N^O)]-tris-heteroleptic Ir(III)-complexes with a horizontal orientation for efficient near-infrared (NIR) polymer light-emitting diodes (PLEDs)》 about this compound( cas:1008-89-5 ) in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. Keywords: polymer light emitting diode heteroleptic iridium complex. We’ll tell you more about this compound (cas:1008-89-5).

Using conventional fac-[Ir(C^N)3]-homoleptic or [Ir(C^N)2(L^X)]-bis-heteroleptic iridium(III)-complexes with NIR-phosphorescence (NIR = near IR) as dopants, the realization of reliable NIR-OLEDs/PLEDs (organic/polymer light-emitting diodes) with high performance remains a real challenge. In this study, taking Hqibt (1-(benzo[b]-thiophen-2-yl)-isoquinoline) as the HC^N1 ligand, Hppy ((phenyl-4-yl)pyridine) as the HC^N2 ligand and Br-Hpic (5-Br-picolinic acid) or Hpic (picolinic acid) as the N^O-ancillary, two novel C1-sym. [Ir(C^N1)(C^N2)(N^O)]-tris-heteroleptic iridium(III)-complexes [Ir(iqbt)(ppy)(pic)] (1) and [Ir(iqbt)(ppy)(Br-pic)] (2) are molecularly designed, resp., where large TDM (transition dipole moment) and strengthened 3MLCT (metal-to-ligand charge transfer) effects are established to afford their good NIR-phosphorescent efficiency (ΦPL = 0.27 for 1 (λem = 698 nm); 0.21 for 2 (λem = 696 nm)). Moreover, in their doped EMLs (emitting layers), a preferentially horizontal orientation of the TDMs is promoted, due to which, the NIR-PLEDs-1-2 exhibit an attractively high efficiency (ηmaxEQE = 3.1-4.7%; λem = 698 nm) as well as an almost negligible (<5%) efficiency roll-off. This finding means the C1-sym. [Ir(C^N1)(C^N2)(N^O)]-tris-heteroleptic Ir(III)-complexes show potential as low-cost, large-area and scalable NIR-PLEDs. There are many compounds similar to this compound(1008-89-5)Recommanded Product: 1008-89-5. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Electric Literature of C11H9N. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Ortho C-H arylation of arenes at room temperature using visible light ruthenium C-H activation. Author is Sagadevan, Arunachalam; Charitou, Anastasios; Wang, Fen; Ivanova, Maria; Vuagnat, Martin; Greaney, Michael F..

A ruthenium-catalyzed ortho C-H arylation process is described using visible light. Using the readily available catalyst [RuCl2(p-cymene)]2, visible light irradiation was found to enable arylation of 2-aryl-pyridines I (R1 = 4-methoxyphenyl, naphthalen-2-yl, thiophen-2-yl, etc.; R2 = H, 2-Me, 4-Me, 5-Me) at room temperature for a range of aryl halides R3X (R3 = 2-methoxyphenyl, 4-phenylphenyl, thiophen-2-yl, etc.; X = I, Br).

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Phenylpyridine(SMILESS: C1(C2=CC=CC=C2)=NC=CC=C1,cas:1008-89-5) is researched.Recommanded Product: cis-Cyclohexane-1,2-dicarboxylic acid. The article 《Visible-Light-Enabled Trifluoromethylative Pyridylation of Alkenes from Pyridines and Triflic Anhydride》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:1008-89-5).

A general strategy for visible-light-enabled site-selective trifluoromethylative pyridylation of unactivated alkenes has been developed using pyridines and triflic anhydride (Tf2O). Intriguingly, the N-triflylpyridinium salts, generated in situ from pyridines and Tf2O, serve as effective modular bifunctional reagents to install both CF3 and pyridyl groups to various olefins while controlling C4-selectivity in radical addition to the pyridine core. This synthetic route exhibited broad substrate scope under metal-free and mild photocatalytic conditions, granting efficient access to valuable C4-alkylated pyridines and quinolines without requiring prefunctionalization of the reaction site.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Science called Molecular engineering enabling reversible transformation between helical and planar conformations by cyclization of alkynes, Author is Yan, Lipeng; Ma, Weixin; Lan, Jingbo; Cheng, Hu; Bin, Zhengyang; Wu, Di; You, Jingsong, which mentions a compound: 1008-89-5, SMILESS is C1(C2=CC=CC=C2)=NC=CC=C1, Molecular C11H9N, Related Products of 1008-89-5.

Mol. engineering enabling reversible transformation between helical and planar conformations was described herein. Starting from easily available 2-(pyridin-2-yl)anilines and alkynes, a one-pot strategy was set up for the synthesis of aza[4]helicenes via two successive rhodium-catalyzed C-H activation/cyclizations. Helical pyrrolophenanthridiziniums was transformed into planar conformations through the cleavage of acidic pyrrole N-H, leading to turn-off fluorescence. NMR spectra, single crystal X-ray diffraction and DFT calculations demonstrated that the formation of an intramol. C-H···N hydrogen bond was beneficial to stabilize the pyrrole nitrogen anion of the planar mol. and provided increased planarity. The reversible conformation transformations was finely adjusted by the electron-donating and -withdrawing groups on the π+-fused pyrrole skeleton in the physiol. pH range, thus affording an opportunity for pH-controlled intracellular selective fluorescence imaging. Pyrrolophenanthridiziniums show turn-on fluorescence in lysosomes owing to the acidic environment of lysosomes and turn-off fluorescence out of lysosomes, indicating the occurrence of the deprotonation reaction outside lysosomes and the corresponding transformation from helical to planar conformations.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Strategically Formulating Aggregation-Induced Emission-Active Phosphorescent Emitters by Restricting the Coordination Skeletal Deformation of Pt(II) Complexes Containing Two Independent Monodentate Ligands.Computed Properties of C11H9N.

Aggregation-induced emission (AIE)-active phosphorescent emitters have intrinsic advantages in time-gated imaging/sensing and improving the electroluminescent efficiencies of organic light-emitting devices (OLEDs). However, compared with the very prosperous and fruitful developments of AIE-active fluorescent emitters and related working mechanisms, the progresses on AIE-active phosphorescent emitters and associated AIE mechanisms are still relatively slow. Herein, the AIE properties of a series of phosphorescent Pt(II) complexes with two monodentate ligands are reported. Compared with the conventional rigid Pt(II) complexes bearing two bidentate ligands or one tri-/tetradentate ligand, the incorporation of two monodentate ligands provides the resulting Pt(II) complexes with more room to deform their coordination skeletons from the square-planar geometry in the ground state to the quasi-tetrahedral configuration in the excited state, causing poor solution emissions. In doped films and aggregate states, intense emissions are observed for these Pt(II) complexes. The as-fabricated solution-processed OLED exhibits an impressively high external quantum efficiency of 21.7%. This study provides an effective way to develop excellent AIE-active phosphorescent emitters.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles