Category: 1015460-59-9

Analyzing the synthesis route of 1015460-59-9

1015460-59-9, 1015460-59-9 7-Bromo-5H-pyrido[4,3-b]indole 71079324, aindole-building-block compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1015460-59-9,7-Bromo-5H-pyrido[4,3-b]indole,as a common compound, the synthetic route is as follows.

Step 3: 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole A mixture of 7-bromo-5H-pyrido[4,3-b]indole (400 mg, 1.63 mmol), (6-fluoropyridin-3-yl)boronic acid (344 mg, 2.44 mmol), PdCl2(dppf) (120 mg, 0.163 mmol), tBu3PHBF4 (95 mg, 0.326 mmol) and Cs2CO3 (1.1 g, 3.26 mmol) in dioxane/water (20 mL, 20:1) was heated to 90 C. for 4 hours under N2. The solid was filtered and the filtrate was evaporated. The residue was purified by chromatography (silica gel, 200-300 mesh, CH2Cl2: MeOH=30:1) to afford 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole (250 mg, 59% yield).

1015460-59-9, 1015460-59-9 7-Bromo-5H-pyrido[4,3-b]indole 71079324, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Arvinas, Inc.; Crew, Andrew P.; Berlin, Michael; Flanagan, John J.; Dong, Hanqing; Ishchenko, Alexey; (559 pag.)US2018/125821; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Downstream synthetic route of 1015460-59-9

The synthetic route of 1015460-59-9 has been constantly updated, and we look forward to future research findings.

1015460-59-9, 7-Bromo-5H-pyrido[4,3-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1015460-59-9, To a solution of custom made 7-bromo-5H-pyrido[4,3-?>]indole (0.49 g, 1.98 mmol) in Lambda/,Lambda/’- dimethylformamide (5 mL) was added cesium carbonate (0.32 g, 0.99 mmol) and the mixture was stirred at room temperature for 10 minutes and dimethylcarbonate was added dropwise (334 mu, 3.96 mmol). The reaction mixture was heated at 160C for 3 hours and after cooling, water (20 mL) and ethyl acetate (20 mL) were added to the mixture. The phases were separated and the aqueous phase was extracted with ethyl acetate (2 X 20 mL). The organic phases were combined and dried over Na2S04. The solvent was removed under reduced pressure and the residue was purified on a HP-Sil column using a Biotage Isolera One purification system employing a dichloromethane/methanol gradient (100/0 -> 90/10) to afford the crude title compound (0.36 g, 69 %). 1H NMR (400 MHz, DMSO-cf6) delta = 9.36 (s, 1 H), 8.52 (d, 1 H), 8.21 (d, 1 H), 7.95 (d, 1 H), 7.62 (d, 1 H), 7.45 (dd, 1 H), 3.88 (s, 3H) MS (ESI): m/z = 263.95 [M+H]+

The synthetic route of 1015460-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AC IMMUNE SA; PIRAMAL IMAGING SA; KROTH, Heiko; NAMPALLY, Sreenivasachary; MOLETTE, Jerome; GABELLIERI, Emanuele; BENDERITTER, Pascal, Andre, Rene; FROESTL, Wolfgang; SCHIEFERSTEIN, Hanno; MUELLER, Andre; SCHMITT-WILLICH, Heribert; BERNDT, Mathias; WO2015/110263; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Analyzing the synthesis route of 1015460-59-9

1015460-59-9 7-Bromo-5H-pyrido[4,3-b]indole 71079324, aindole-building-block compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1015460-59-9,7-Bromo-5H-pyrido[4,3-b]indole,as a common compound, the synthetic route is as follows.

Compound P (500 mg, 2.02 mmol), compound Q (655 mg, 2.23 mmol), NaHC03 (510 mg, 6.06 mmol), and Pd(dppf)2Cl2 (70 mg) in MeCN and H20 (4:1, 10 mL) were stirred at 90 C for 30 min. The reaction mixture was cooled to r.t., diluted with H20 (50 mL), and extracted with DCM (3 x 100 mL). The organics were combined and concentrated in vacuo. The resulting solid was washed with cold DCM (3 mL) to afford compound R as a white powder, which was used without further purification (340 mg, 1.02 mmol, 51 %). MS (ESI) m/z 334 (M+H)+, 1015460-59-9

1015460-59-9 7-Bromo-5H-pyrido[4,3-b]indole 71079324, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael S.; HAGGARTY, Stephen J.; CAI, Quan; TELO BAPTISTA LIMA DA SILVA, Maria Catarina; ZHANG, Tinghu; FERGUSON, Fleur M.; (220 pag.)WO2019/14429; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles