Category: 101774-27-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101774-27-0,6-Bromo-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Step 9; -Bromo-lH-indole-S-carboxylic acid methyl ester; Acetyl chloride (29,43 g, 374 mmol) is added slowly at room temperature to a solution of 6-bromo-indole-3-carboxylic acid (45 g, 187.46 mmol) in 50OmL of methanol and the resulting solution is stirred at 650C overnight. The reaction is cooled to room temperature. A white precipitates appears when cooling. After stirring 2h at room temperature, the solid is filtered off and dried under vacuum. 34.4g (72%) of the title compound is obtained as a light brown solid. MS (m/e): 254 (M+ 1)

101774-27-0, 101774-27-0 6-Bromo-1H-indole-3-carboxylic acid 15284837, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2009/12125; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

101774-27-0, 6-Bromo-1H-indole-3-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 250 mL round bottom Hask was added 6-bromo-l H-indole-3-carboxylic acid ASa(5 g, 20.83 mmol, 1.0 equiv.), N,N-dimethylformamide (150 mL), Mel (5.9 g), andsodium hydride (3.5 g, 145.83 mmol, 7.0 equiv.). The resulting mixture ‘.Vas stirred at 10-25 oc for l h, a.nd then diluted with 1500 mL ofH?O. The aqueous mixture was extracted15 with ethyl acetate (200 mL x 3) and the combined organic layers were dried over anhydrousmagnesium sulfate, filtered, and concentrated in vacuo. The cmde product was purified byre-crystallization from PE. The solids were collected by filtration to yield 3.5 g (63%) ofmethyl 6-brorno-l-methyl-l H-indole-3-carboxylate A-8b a.s a light yellow solid.

101774-27-0, The synthetic route of 101774-27-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles