1071973-95-9, 6-Methoxy-5-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of intermediate 10a: Diethylaluminum chloride 1 M in hexane (18.6 ml_, 18.6 mmol) was added dropwise at 0C to a solution of 6-methoxy-5-methyl-1 H-indole [CAS 1071973- 95-9] (2 g, 12.4 mmol) in CH2CI2(60 ml_). After 30 min at 0C, 2-(4-fluoro-2- methoxyphenyl)acetyl chloride 1a (3.3 g, 16.3 mmol, synthesis: see Example 1 ) in CH2CI2 (60 ml_) was added slowly at 0C. The reaction was stirred at 0C for 3 h. Ice-water was added and the precipitate was filtered off, washed with water, and dried under vacuum to provide 2-(4-fluoro-2-methoxyphenyl)-1 -(6-methoxy-5- methyl-1 H-indol-3-yl)ethanone 10a (3.15 g)., 1071973-95-9
The synthetic route of 1071973-95-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; KESTELEYN, Bart, Rudolf, Romanie; BONFANTI, Jean-Francois; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; BARDIOT, Dorothee, Alice, Marie-Eve; MARCHAND, Arnaud, Didier, M; (86 pag.)WO2016/113371; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles