Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Formula: C10H8FNO2, Which mentioned a new discovery about 1082040-43-4
Anti-ovarian cancer drug Rucaparib key intermediate of the preparation method, relates to the preparation of the intermediate compound. Compound 1 to methanol and cyclohexane as solvent, toluenesulfonic acid as catalyst, after the reaction to obtain compound 2; in order to acetic acid and acetic anhydride as the solvent, the compound 2 with potassium nitrate reaction, to obtain compound 3; compound 3 in order to N, N – dimethyl formamide dimethyl acetal as a solvent, the triethylamine as a catalyst, reaction, to obtain compound 4; compound 4 to methanol as a solvent, Raney nickel as catalyst, reaction, to obtain compound 5, namely the anti-ovarian cancer drug Rucaparib key intermediate: 6 – fluoro – 1 H – indazole – 4 – carboxylic acid methyl ester. To avoid niter sulfur nitration mixture nitration and waste water and waste gas discharge, safety and environmental protection. Raw materials are easy and low price, improves the reaction yield, is suitable for industrial production. (by machine translation)
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Formula: C10H8FNO2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1082040-43-4
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles