With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1082040-57-0,Methyl 6-chloro-1H-indole-4-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of methyl 6-chloro-1H-indole-4-carboxylate (1000 mg, 4.77 mmol) in tetrahydrofuran (20 mL) was added allyl alcohol (0.324 mL, 4.77 mmol), and the mixture was degassed for 5 minutes by bubbling nitrogen. Triethylborane (1.431 mL, 1.431 mmol) and tetrakis(triphenylphosphine)palladium(0) (276 mg, 0.239 mmol) were added and the mixture was heated to 75 C and stirred at 75 C for 18 hours. The mixture was concentrated and the residue was purified using column chromatography (silica gel, 0 to 70% EtOAc in hexanes) to afford methyl 3-allyl-6-chloro-lH-indole-4-carboxylate (714 mg, 60%) as a white solid. LC-MS(ES) m/z = 250 [M+H]+., 1082040-57-0
1082040-57-0 Methyl 6-chloro-1H-indole-4-carboxylate 53399422, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; MILLER, William Henry; ROMERIL, Stuart Paul; VERMA, Sharad Kumar; TIAN, Xinrong; WO2015/132765; (2015); A1;,
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