In an article, author is Boosa, Venu, once mentioned the application of 109-00-2, Safety of Pyridin-3-ol, Name is Pyridin-3-ol, molecular formula is C5H5NO, molecular weight is 95.1, MDL number is MFCD00006378, category is indole-building-block. Now introduce a scientific discovery about this category.
The dispersed on mesoporous SBA-15 has demonstrated the regioselective C-H bond C-3-cyanation of indoles by in-situ generation of -CN using DMF and NH4I in presence of O-2. Pyridine adsorbed diffuse reflectance infrared spectroscopy (DRIFTS) results revealed that surface Cu2+ species are acting as Lewis acid sites in the in-situ generation of cyano-group for the synthesis of indole nitriles. A direct correlation between Cu metal surface area and the indole nitrile yields are established and the dual role of copper is substantiated by N2O titration and XPS techniques. The 10 wt%Cu/SBA-15 demonstrated superior performance when compared to Pd, Ru supported on SBA-15. The 10 wt%Cu/SBA-15 catalyst showed consistent activity and selectivity after the 4th cycle. (C) 2017 Elsevier B.V. All rights reserved.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles