With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1098340-27-2,Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.,1098340-27-2
General procedure: Method B: to a solution of N-chlorosuccinimide (1.2 eq.) in DMF (0.3 M) was added sodium iodide (1.2 eq.) in small portion. The resulting brown solution was stirred at room temperature for 1 h before the slow addition at 0 C of the corresponding indole (1.0 eq.) in DMF (0.3 M). The reaction mixture was stirred at room temperature overnight. A saturated aqueous solution of sodium thiosulfate and water were added and the mixture was stirred for 1 h. After filtration, the crude material was washed with cold water and cold petroleum ether to afford after drying under high vacuum the attempted 3-iodoindole which was used in the next step without any further purification. Compounds 24 (method B), 22-35 (method A) were previously described [11], [18] and [19].
The synthetic route of 1098340-27-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Neagoie, Cleopatra; Vedrenne, Emeline; Buron, Frederic; Merour, Jean-Yves; Rosca, Sorin; Bourg, Stephane; Lozach, Olivier; Meijer, Laurent; Baldeyrou, Brigitte; Lansiaux, Amelie; Routier, Sylvain; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 379 – 396;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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