Category: 110-52-1

Recommanded Product: 1,4-Dibromobutane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Dicationic liquid containing alkenyl modified CuBTC improves the performance of the composites: Increasing the CO2 adsorption effect. Author is Pan, Rong; Guo, Yanni; Tang, Yining; Wei, Dong; Liu, Mengli; He, Deliang.

Two novel di-cation liquid-copper-based Cu-BTC (DILs/CuBTC) were obtained by modifying CuBTC with dicationic ionic liquids 3,3′-(butane-1,4-diyl)bis(1-methyl-1H-imidazol-3-ium)bromide([C4(i.m.)2]Br2) and 3,3′-(butane-1,4-diyl)bis(1-vinyl-1H-imidazol-3-ium)bromide([C4(Vim)2]Br2) were used to modify CuBTC. SEM, XRD, FTIR, BET, and TG characterized the morphol., structure, and thermal stability of the DILs/CuBTC. The results show that hydrogen bonding recombines DILs and CuBTC, and the DILs modification does not destroy the original framework structure of CuBTC. The adsorption properties and mechanism of the DILs/CuBTC for CO2 adsorption were also studied. DILs /CuBTC has a better CO2 adsorption effect than CuBTC, because the long chains of DILs and newly formed hydrogen bonds provide new active sites. Studies have found DIL-2/CuBTC that CuBTC modified by [C4(Vim)2]Br2 has the largest sp. surface area and exhibits the best adsorption performance. It may be that the alkenyl groups on DILs can strengthen the interaction between DILs and CuBTC through π-π force, conducive to the dispersion of DIL and the formation of the composite. Time, adsorbent dose, and CO2 concentration effects on the adsorption of CO2 were studied. At 293 K, the maximum theor. adsorption capacity (qm) of DIL-2/CuBTC for CO2 is 44.93 mmol g-1, 114.67% higher than CuBTC. Both the pseudo-second-order model and Freundlich model fit the adsorption data well. DIL-2/CuBTC has excellent repeatability and cyclic stability, it can be used as an effective adsorbent for CO2 and other toxic gases.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Antibacterial, antibiofilm, anti-inflammatory, and wound healing effects of nanoscale multifunctional cationic alternating copolymers.Quality Control of 1,4-Dibromobutane.

Infectious diseases caused by new or unknown bacteria and viruses, such as anthrax, cholera, tuberculosis and even COVID-19, are a major threat to humanity. Thus, the development of new synthetic compounds with efficient antimicrobial activity is a necessity. Herein, rationally designed novel multifunctional cationic alternating copolymers were directly synthesized through a step-growth polymerization reaction using a bivalent electrophilic crosslinker containing disulfide bonds and a diamine heterocyclic ring. To optimize the activity of these alternating copolymers, several different diamines and crosslinkers were explored to find the highest antibacterial effects. The synthesized nanopolymers not only displayed good to excellent antibacterial activity as judged by min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli, but also reduced the number of biofilm cells even at low concentrations, without killing mammalian cells. Furthermore, in vivo experiments using infected burn wounds in mice demonstrated good antibacterial activity and stimulated wound healing, without causing systemic inflammation. These findings suggest that the multifunctional cationic nanopolymers have potential as a novel antibacterial agent for eradication of multidrug resistant bacterial infections.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,4-Dibromobutane( cas:110-52-1 ) is researched.COA of Formula: C4H8Br2.Yang, Lu; Nie, Cui-Yun; Han, Ying; Sun, Jing; Yan, Chao-Guo published the article 《Self-assembly of bis-[1]rotaxanes based on diverse thiourea-bridged mono-functionalized dipillar[5]arenes》 about this compound( cas:110-52-1 ) in Journal of Inclusion Phenomena and Macrocyclic Chemistry. Keywords: bisrotaxane thiourea dipillararene self assembly NOESY spectra. Let’s learn more about this compound (cas:110-52-1).

Abstract: The condensation reaction of mono-amido-functionalized pillar[5]arenes with tere- and iso-phthaloyl diisothiocyanates in acetone under ultrasonic irradiation afforded tere- and iso-phthaloylthiourea-bridged dipillar[5]arenes. The similar reaction of mono-amido-functionalized pillar[5]arenes with 1,ω-bis(4-isothiocyanatophenoxy)alkanes also afforded diphenoxyalkylene thiourea-bridged dipillar[5]arenes. 1H NMR and NOESY spectra clearly indicated that bis-[1]rotaxanes were formed by insertion of longer alkylene chains into the cavities of two pillar[5]arenes. On the other hand, the free-forms of dipillar[5]arenes were obtained with the shorter ethylene chains existing on the outside of the cavities of two pillar[5]arenes.

In addition to the literature in the link below, there is a lot of literature about this compound(1,4-Dibromobutane)COA of Formula: C4H8Br2, illustrating the importance and wide applicability of this compound(110-52-1).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes》. Authors are de Juan, Alberto; Lozano, David; Heard, Andrew W.; Jinks, Michael A.; Suarez, Jorge Meijide; Tizzard, Graham J.; Goldup, Stephen M..The article about the compound:1,4-Dibromobutanecas:110-52-1,SMILESS:BrCCCCBr).Application In Synthesis of 1,4-Dibromobutane. Through the article, more information about this compound (cas:110-52-1) is conveyed.

A combination of reaction partners that function as a chiral interlocking auxiliary to both orientate a macrocycle and effectively, load it onto a new axle was discovered. These substrates was used to demonstrate the potential of a chiral interlocking auxiliary strategy for the synthesis of mech. planar chiral rotaxanes by producing a range of examples with high enantiopurity (93-99% e.e.), including so-called ′impossible′ rotaxanes whose axles lack any functional groups that would allow their direct synthesis by other means. Intriguingly, by varying the order of bond-forming steps, can effectively choose which end of an axle the macrocycle is loaded onto, enabling the synthesis of both hands of a single target using the same reactions and building blocks.

In addition to the literature in the link below, there is a lot of literature about this compound(1,4-Dibromobutane)Application In Synthesis of 1,4-Dibromobutane, illustrating the importance and wide applicability of this compound(110-52-1).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors. Author is Wei, Huiqiang; Guo, Jianghong; Sun, Xiao; Gou, Wenfeng; Ning, Hongxin; Fang, Zhennan; Liu, Qiang; Hou, Wenbin; Li, Yiliang.

SUMOylation and deSUMOylation plays an important role in DNA damage response and the formation of radiotherapy resistance. SENP1 is the main specific isopeptidase to catalyze deSUMOylation modification. Inhibiting SENP1 upregulates cancer cell radiosensitivity and it becomes a promising target for radiosensitization. Herein, based on the structure of ursolic acid (UA), a total of 53 pentacyclic triterpene derivatives were designed and synthesized as SENP1 inhibitors. Ten derivatives exhibited better SENP1 inhibitory activities than UA and the preliminary structure-activity relationship was discussed. Most of the UA derivatives were low-cytotoxic, among which compound 36 showed the best radiosensitizing activity with the SER value of 1.45. It was the first study to develop small mol. SENP1 inhibitors as radiosensitizers.

In addition to the literature in the link below, there is a lot of literature about this compound(1,4-Dibromobutane)Category: indole-building-block, illustrating the importance and wide applicability of this compound(110-52-1).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Accessing Polycyclic Heteroarenes Enabled by Copper-Catalyzed Aerobic Oxidative C-H/C-H [4 + 2] Annulation of 3-Arylindole Derivatives.HPLC of Formula: 110-52-1.

Several polycyclic aromatic hydrocarbons I (R = Ph, naphthalen-2-yl, 3,4-difluorophenyl, etc.; R1 = H, t-Bu, trifluoromethyl, ethoxycarbonyl; R2 = H, 3-Me, 4-OMe, 2,3-dichloro, etc.; R3R4 = -(CH=CH-CH=CH)-) are delivered at room temperature by copper-catalyzed aerobic oxidative C-H/C-H [4 + 2] annulation of alkyl-substituted 3-arylindole derivs II (R5 = 4-phenylbut-3-yn-1-yl, 2-(2-phenylethynyl)phenyl, 2-[2-(4-chlorophenyl)ethynyl]benzen-1-yl, etc.). Specifically, dual aryl C-H functionalization is furnished under mild conditions through the 1,2-migration of copper catalyst and regioselective alkyne insertion. Mechanistic experiments demonstrate that the C-H bond cleavage on the indole and Ph rings is not involved in the rate-limiting step.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 1,4-Dibromobutane. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Synthesis and Characterization of Compounds Based on Carbazole and Sulfone Groups.

Two compounds containing carbazole and sulfone groups with different alkyl chain lengths have been designed and synthesized. The sulfone group has strong absorption characteristics and the alkoxy chain and carbazole group are electron-rich, forming D-δ-A-type sym. mols. The mols. have the characteristics of charge transfer and high thermal stability, and the mols. stack to form a layered staggered stack, reducing the intermol. π-π interactions. The target compounds also exhibit strong UV-fluorescent emission in the solid state at room temperature, and they are expected to be good luminescent materials.

There are many compounds similar to this compound(110-52-1)Quality Control of 1,4-Dibromobutane. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Exploring Electrochemical C(sp3)-H Oxidation for the Late-Stage Methylation of Complex Molecules, published in 2022-01-26, which mentions a compound: 110-52-1, Name is 1,4-Dibromobutane, Molecular C4H8Br2, Reference of 1,4-Dibromobutane.

A modular, efficient and selective strategy for the α-methylation of protected amines (i.e., amides, carbamates and sulfonamides) by means of electrochem. oxidation was disclosed. Mechanistic anal. guided to develop an improved electrochem. protocol on the basis of the classic Shono oxidation reaction, which featured broad reaction scope, high functional group compatibility and operational simplicity. Importantly, this reaction system was amenable to the late-stage functionalization of complex targets containing basic nitrogen groups that was prevalent in medicinally active agents. When combined with organozinc-mediated C-C bond formation, this protocol enabled the direct methylation of a myriad of amine derivatives including those that have previously been explored for the “”magic methyl”” effect. This synthetic strategy thus circumvented multistep de novo synthesis that was currently necessary to access such compounds and has the potential to accelerate drug discovery efforts.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy called Emissive and reactive excimers in a covalently-linked supramolecular multi-chromophoric system with a balanced rigid-flexible structure, Author is Budyka, Mikhail F.; Gavrishova, Tatiana N.; Li, Vitalii M.; Potashova, Natalia I.; Fedulova, Julia A., which mentions a compound: 110-52-1, SMILESS is BrCCCCBr, Molecular C4H8Br2, HPLC of Formula: 110-52-1.

A novel multi-chromophoric system, triad, in which two styrylbenzoquinoline (SBQ) photochromes were connected by a balanced rigid-flexible linker comprising 2,3-naphthylene framework (a residue of 3-oxy-2-naphthoic acid) and tetramethylene groups, was designed and synthesized to study an excimer formation in the excited state. The 1H NMR data testified that triad exists in solution as folded conformers with asym. parallel-displaced SBQ units. Under light irradiation, in the triad, competitive photoisomerization and [2 + 2] photocycloaddition reactions were observed, both reactions being reversible. The photocycloaddition resulted in a tetrasubstituted cyclobutane. The red-shifted fluorescence spectrum and the appearance of a long-lived component in the triad fluorescence decay indicated formation of an ’emissive’ excimer. The photocycloaddition was assumed to occur in a ‘reactive’ excimer, in which the ethylene groups of the SBQ photochromes were located at a distance sufficient for the formation of the σ-bonds between them. Quantum-chem. d. functional theory (DFT) calculations at M06-2X/6-31G* level predicted the existence of the triad conformers with π-stacking interaction of SBQ photochromes, the structure of which is pre-organized for the excimer formation and photocycloaddition For the first time, both emissive and reactive excimers were exptl. observed in the multi-chromophoric system with two diarylethylene photochromes undergoing [2 + 2] photocycloaddition

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Ascorbic acid specifically reduces the misclassification of nonirritating reactive chemicals in the OptiSafe macromolecular eye irritation test. Author is Lebrun, Stewart; Chavez, Sara; Chan, Roxanne; Nguyen, Linda; Jester, James V..

Recently, we showed that the addition of physiol. concentrations of ascorbic acid, a tear antioxidant, to the OptiSafe macromol. eye irritation test reduced the false-pos. (FP) rate for chems. that had reactive chemistries, leading to the formation of reactive oxygen species (ROS) and mol. crosslinking. The purpose of the current study was to 1) increase the number of chems. tested to comprehensibly determine whether the antioxidant-associated reduction in OD is specific to FP chems. associated with ROS chemistries and 2) determine whether the addition of antioxidants interferes with the detection of true pos. (TP) and true neg. (TN) ocular irritants. We report that when ascorbic acid is added to the test reagents, retesting of FP chems. with reactive chemistries show significantly reduced OD values (P < 0.05). Importantly, ascorbic acid had no significant effect on the OD values of TP or TN chems. regardless of chem. reactivity. These findings suggest that supplementation of ascorbic acid in alternative ocular irritation tests may help improve the detection of TN for those commonly misclassified reactive chems. Here is just a brief introduction to this compound(110-52-1)Category: indole-building-block, more information about the compound(1,4-Dibromobutane) is in the article, you can click the link below.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles