Category: 110-52-1

SDS of cas: 110-52-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Potassium reduced graphite functionalization: Architectural aesthetics and electrical excellence. Author is Bai, Li; Xu, Yongqi; Hu, Cheng-Min; Dong, Lei; Wang, Xinping; Li, Wei-Shi; Zhao, Fu-Gang.

Rational functionalization plays an important role to push forward graphene applications in multifarious cutting-edge technologies. A key topic that how to program the regular distribution of functional groups, however, remains a big challenge. Herein, we developed a very simple, high-throughput graphite reduction methodol. to attain the neg.-charged graphene which carried ultrahigh-d. and evenly-distributed neg. charges. Guided by these neg. charges, electrophiles were regularly attached to graphene sheets. On the other hand, potassium reduction will not break the carbon-carbon σ-bonds, hence graphene hexagonal lattice was kept as perfect as the pristine pattern. Structural advantages of the neg.-charged graphene derivatives allowed a far more excellent conductivity and electron mobility than the counterparts derived from the prevalent graphene oxide precursor.

There is still a lot of research devoted to this compound(SMILES：BrCCCCBr)SDS of cas: 110-52-1, and with the development of science, more effects of this compound(110-52-1) can be discovered.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 110-52-1, is researched, Molecular C4H8Br2, about Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues, the main research direction is dihydrexidine SKF catecholamine analog dopamine receptor binding; D1R agonists; D2R and DAT; Dihydrexidine; Dopamine analogs; SKF 38393.Application of 110-52-1.

Dopamine is an important neurotransmitter that regulates numerous essential functions, including cognition and voluntary movement. As such, it serves as an important scaffold for synthesis of novel analogs as part of drug development effort to obtain drugs for treatment of neurodegenerative diseases, such as Parkinson′s disease. To that end, similarity search of the ZINC database based on two known dopamine-1 receptor (D1R) agonists, dihydrexidine (DHX) and SKF 38393, resp., was used to predict novel chem. entities with potential binding to D1R. Three compounds that showed the highest similarity index were selected for synthesis and bioactivity profiling. All main synthesis products as well as the isolated intermediates, were properly characterized. The physico-chem. analyses were performed using HRESIMS, GC/MS, LC/MS with UV-Vis detection, and FTIR, 1H NMR and 13C NMR spectroscopy. Binding to D1 and D2 receptors and inhibition of dopamine reuptake via dopamine transporter were measured for the synthesized analogs of DHX and SKF 38393.

Here is a brief introduction to this compound(110-52-1)Application of 110-52-1, if you want to know about other compounds related to this compound(110-52-1), you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,4-Dibromobutane( cas:110-52-1 ) is researched.COA of Formula: C4H8Br2.Feng, Yiyue; Lu, Yingmei; Li, Junfang; Zhang, Honghua; Li, Zhao; Feng, Hanzhong; Deng, Xuemei; Liu, Dan; Shi, Tao; Jiang, Weifan; He, Yongxing; Zhang, Jian; Wang, Zhen published the article 《Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo》 about this compound( cas:110-52-1 ) in European Journal of Medicinal Chemistry. Keywords: o aminobenzamide antigastric cancer agents; Cell cycle analysis; Gastric cancer; Migration and invasion; Structure-activity relationship; o-Aminobenzamide derivatives. Let’s learn more about this compound (cas:110-52-1).

Although gastric cancer has become a major public health problem, oral agents applied in clinics for gastric cancer therapy are scarce. Therefore, to explore new oral chem. entities with high efficiency and low toxicity, 41 o-aminobenzamide derivatives based on the scaffolds of MS-275 and SAHA were designed, synthesized, and evaluated for their anti-gastric cancer abilities in vitro and in vivo. Structure-activity relationships were discussed, leading to the identification of compounds F8 (IC50 = 0.28 μM against HGC-27 cell) and T9 (IC50 = 1.84 μM against HGC-27 cell) with improved cytotoxicity, anti-gastric cancer proliferation potency, induction of cell apoptosis and cell cycle arrest ability, inhibition of cell migration and invasion. What is worth mentioning is that compound F8 was more efficient and less toxic than the pos. drug capecitabine in vivo on the HGC-27-xenograft model. Meanwhile, compound F8 exhibited suitable pharmacokinetic properties and less acute toxicity (LD50 > 1000 mg/kg). Besides, western blotting anal., IHC anal., differentially expressed proteins anal. and ABPP experiment indicated that compound F8 could modulate mol. pathways involved in apoptosis and cell cycle progression. Consequently, compound F8 is a strong candidate for the development of human gastric cancer therapy.

If you want to learn more about this compound(1,4-Dibromobutane)COA of Formula: C4H8Br2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(110-52-1).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles