With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.110543-98-1,Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate,as a common compound, the synthetic route is as follows.
Thiophenoi (99.8 pL, 0.972 rnol, 1 .0 eq.) was added to a solution of potassium hydroxide (164 mg, 2,92 -mmol, 3.0 eq.) in methanol {2 ml) and left to stir at room temperature for 15 min. Afte this time, the solution was cooled on ice and bromo indole 2 (880 nig, 0,972 mmol, 10 eq.) in CH2.CJ2 (5 mL) was added. The reaction was left to stir for 3 h before neutralisation with acetic acid. The solvent was removed in vacuo and columned directly (20% EiOAc in petrol) to yield the title product as a pale yellow solid {362 mg, 86%). UUR deltaEta (600 MHz, CDCb) 7.74 (s, 1 H , Hr), 7.43 (s, 1H, H4), 7.36 (dq, J – 5.2, 3.4, 2.4 Hz, 2H, Hw), 7.25
As the paragraph descriping shows that 110543-98-1 is playing an increasingly important role.
Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; WILSON, Ian, A.; WOLAN, Dennis, W.; WRIGHT, Zoe, V, .F.; KADAM, Rameshwar, U.; WU, Nicholas, C.; (28 pag.)WO2018/112128; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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