Category: 112656-95-8

Synthesis and screening of 2-hydroxy-N-(2,41-dioxospiro [indoline-3,21-thiazolidin]-31-yl) benzamides for antiinflammatory activity was written by Devi, N. Saritha;Sarangapani, Manda. And the article was included in International Journal of Pharmacy and Biological Sciences in 2018.SDS of cas: 112656-95-8 This article mentions the following:

A novel synthesis of 2-hydroxy-N-(2,4′-dioxospiro[indoline-3,2′-thiazolidin]-3′-yl)benzamide derivatives I [R = H, 5-F, 5,6-dichloro, etc.] was synthesized by cyclization of isatin hydrazones with thioglycollic acid. The synthesized compounds I were characterized by spectral data (IR, ¹H-NMR, MASS) and evaluated for in-vitro, in-vivo anti-inflammatory activity. The test compounds I exhibited significant potency to inhibit COX-2 enzyme values between 46.23 鍗?0.38 to 73.24 鍗?0.35, Among the tested compounds compounds I [R = 5,6-dichloro, 5-F, 5-Cl] were considered to possess more potent anti-inflammatory activity when compared to standard drug indomethacin. By in-vitro anti-inflammatory activity the compounds I [R = 5,6-dichloro, 5-F, 5-Cl, 5-Br] were considered to possess more potent anti-inflammatory activity when compared to standard drug indomethacin. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8SDS of cas: 112656-95-8).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.SDS of cas: 112656-95-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from鑱紹acillus thuringiensis鑱絘nd鑱紹acillus velezensis鑱絘nd their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Improved synthesis of 3-spiro indolines in dry media under microwave irradiation was written by Dandia, Anshu;Sachdeva, Harshita;Singh, Ruby. And the article was included in Synthetic Communications in 2001.Synthetic Route of C8H4N2O4 This article mentions the following:

The spiro[indole-dipyrrolopyridines] I (X = NH; R = H, Me; R¹, R² = F, H; H, NO₂; Me, Me; NO₂, H; H, NO₂) were prepared in an efficient, one-pot synthesis using microwave irradiation by reaction of spiro[indole-dipyrrolopyrans] I (X = O) with ammonium acetate in the presence of acetic acid. I (X = O) were prepared in situ by microwave induced reaction of indole-2,3-diones and 2-pyrrolidones in a 1:2 molar ratio. Comparative studies were made between microwave irradiation of reactants in the absence of any solvent and catalyzed reactions in the presence of o-dichlorobenzene and classical heating. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Synthetic Route of C8H4N2O4).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Synthetic Route of C8H4N2O4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from鑱紹acillus thuringiensis鑱絘nd鑱紹acillus velezensis鑱絘nd their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Antioxidant and DNA binding study of 2,2¹-(5,5′-methylenebis(1,3,4-oxadiazole-5,2-diyl)bis(sulfanyl)acetic acid bis(2-oxo-3-indolyl)hydrazides was written by Rani, S. Shobha;Agaiah, Bairi;Sarangapani, M.. And the article was included in International Journal of Chemical Sciences in 2010.COA of Formula: C8H4N2O4 This article mentions the following:

The synthesis of the target compounds was achieved by a reaction of 1H-indole-2,3-dione derivatives with hydrazine and chloroacetyl chloride, formation of 2-chloroacetic acid 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide derivatives, subsequent reaction with 5,5′-methylenebis[1,3,4-oxadiazole-2(3H)-thione] and the products thus obtained were confirmed by elemental anal., IR, NMR, MS. The title compounds were evaluated for their radical scavenging properties using a DPPH radical model [2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazinyl radical] and it was discovered that these compounds displayed antioxidant activity in comparison with ascorbic acid. The compounds were also evaluated in a herring sperm DNA model and it was discovered that these products displayed DNA binding properties in using cisplatin as a drug standard In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8COA of Formula: C8H4N2O4).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C8H4N2O4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from鑱紹acillus thuringiensis鑱絘nd鑱紹acillus velezensis鑱絘nd their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and screening of 2-hydroxy-N-(2,41-dioxospiro [indoline-3,21-thiazolidin]-31-yl) benzamides for antiinflammatory activity was written by Devi, N. Saritha;Sarangapani, Manda. And the article was included in International Journal of Pharmacy and Biological Sciences in 2018.SDS of cas: 112656-95-8 This article mentions the following:

A novel synthesis of 2-hydroxy-N-(2,4′-dioxospiro[indoline-3,2′-thiazolidin]-3′-yl)benzamide derivatives I [R = H, 5-F, 5,6-dichloro, etc.] was synthesized by cyclization of isatin hydrazones with thioglycollic acid. The synthesized compounds I were characterized by spectral data (IR, ¹H-NMR, MASS) and evaluated for in-vitro, in-vivo anti-inflammatory activity. The test compounds I exhibited significant potency to inhibit COX-2 enzyme values between 46.23 ± 0.38 to 73.24 ± 0.35, Among the tested compounds compounds I [R = 5,6-dichloro, 5-F, 5-Cl] were considered to possess more potent anti-inflammatory activity when compared to standard drug indomethacin. By in-vitro anti-inflammatory activity the compounds I [R = 5,6-dichloro, 5-F, 5-Cl, 5-Br] were considered to possess more potent anti-inflammatory activity when compared to standard drug indomethacin. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8SDS of cas: 112656-95-8).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.SDS of cas: 112656-95-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Improved synthesis of 3-spiro indolines in dry media under microwave irradiation was written by Dandia, Anshu;Sachdeva, Harshita;Singh, Ruby. And the article was included in Synthetic Communications in 2001.Synthetic Route of C8H4N2O4 This article mentions the following:

The spiro[indole-dipyrrolopyridines] I (X = NH; R = H, Me; R¹, R² = F, H; H, NO₂; Me, Me; NO₂, H; H, NO₂) were prepared in an efficient, one-pot synthesis using microwave irradiation by reaction of spiro[indole-dipyrrolopyrans] I (X = O) with ammonium acetate in the presence of acetic acid. I (X = O) were prepared in situ by microwave induced reaction of indole-2,3-diones and 2-pyrrolidones in a 1:2 molar ratio. Comparative studies were made between microwave irradiation of reactants in the absence of any solvent and catalyzed reactions in the presence of o-dichlorobenzene and classical heating. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Synthetic Route of C8H4N2O4).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Synthetic Route of C8H4N2O4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and characterization of new indole derivatives for analgesic activity was written by Blessi, Priyanka K.;Maharaj, Pogula;Suresh, S.;Thirupathi, K.;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2012.Product Details of 112656-95-8 This article mentions the following:

A series of indole derivatives I(R =H, 7-Cl, 5-Cl, 5-Br, 5-CO₂H, 5-Me, 5-NO₂, 7-NO₂, 7-CO₂Me) were prepared and profiled as antipyretic compounds All the synthesized derivatives were characterized by chromatog., IR, ¹H NMR and MASS spectral anal. The synthesized derivatives were evaluated for in vivo analgesic activity by using Diclofenac sodium as a standard Prepared compound (R = 5-NO₂) showed potent activity when compared to Diclofenac sodium. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Product Details of 112656-95-8).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Product Details of 112656-95-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Polycyclic heterocycles with acidic N-H group. Part VI. The synthesis of some polycyclic heterocyclic compounds related to 3-phenyl-1,2-dihydroquinoxalin-2-one was written by Frysova, Iveta;Slouka, Jan;Gucky, Tomas. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2005.Formula: C8H4N2O4 This article mentions the following:

This work deals with the study of the reactivity of substituted 3-(2-aminophenyl)-1,2-dihydroquinoxalin-2-ones. 3-(2-Amino-4-fluorophenyl)-1,2-dihydroquinoxalin-2-one (I) was prepared by the reaction of 6-fluoro-N-acetylisatin with 1,2-diaminobenzene and further hydrolysis of the acetyl group. The resp. 3-(2-amino-3-nitrophenyl) compound (II) was prepared directly by the reaction of 7-nitroisatin with 1,2-diaminobenzene. Subsequent cyclization of I and II in POCl₃ afforded the corresponding indolo[2,3-b]quinoxalines. Intramol. splitting cyclizations of diazonium salts derived from I and II led to [1]benzofuro[2,3-b]quinoxalines and azo-coupling reactions of the diazonium salts with Et cyanoacetylcarbamate and malonodinitrile gave arylhydrazones. These arylhydrazones were then transformed into 1,3-diaminopyrazoles and 6-azauracils. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Formula: C8H4N2O4).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Formula: C8H4N2O4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and evaluation of new isatin derivatives for cytotoxic activity was written by Priyanka, K. Blessi;Manasa, C.;Sammaiah, G.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2014.Computed Properties of C8H4N2O4 This article mentions the following:

A series of semicarbazones I (R = 5-Br, 7-NO₂, 5-CH₃, etc.) was synthesized and screened for their cytotoxic activity by MTT assay method. All synthesized compounds I exhibited significant cytotoxicity in a concentration-dependent manner. The IC₅₀ values of all test compounds I were found to be between 19.27 and 52.45 mM for MCF-7 cell lines and between 14.10 and 31.6 mM for HeLa cell lines. All the synthesized compounds have shown moderate antioxidant activity. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Computed Properties of C8H4N2O4).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Computed Properties of C8H4N2O4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Antibacterial and cytotoxic activity of 3, 3′-(5,5′-methylene bis(3-mercapto-4H-1,2,4-triazole-5,4-diyl) bis (azan-1-yl-1-ylidene) diindolin-2-ones was written by Rani, S. Shobha;Ajitha, M.;Agaiah, Bairi;Sarangapani, M.. And the article was included in Journal of Chemical and Pharmaceutical Sciences in 2010.Related Products of 112656-95-8 This article mentions the following:

Indolinones I (R¹ = H, R² = 5-F, 5-Me, 6-Br, etc.) were synthesized by the condensation of an appropriate isatin with 5,5¹-methylenediyl-bis(4-amino-4H-1,2,4-triazole-3-thiol). Compounds I were screened for cytotoxic activity using A-549 Lung cancer and HT-29 Colon cancer cell lines by MTT method and antibacterial activity against B. subtilis, S. aureus, E. coli and S. typhi by cup plate method. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Related Products of 112656-95-8).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Related Products of 112656-95-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and characterization of cytotoxic activity of certain n-(6-benzoyl-1H-benzo [d] imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2014.Formula: C8H4N2O4 This article mentions the following:

A series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides I [R = H, 5-CH₃, 5-Cl, 5-Br, 5-NO₂, 7-NO₂, 7-CH₃] were synthesized by treating (5-benzoyl-1H-benzo[d]imidazol-2-yl) carbamates II with different substituted isatins. All the synthesized derivatives I were screened for anticancer activity against Hela using MTT assay and produced a dose dependent inhibition of growth of the cells. The IC₅₀ values of all the synthetic test compounds were found between 16.03 to 41.75. The potency of (IC₅₀ values) of cytotoxicity of compounds was compared with that of known cytotoxic agent, Cisplatin. Among all the synthesized novel compound I (R = 5-Cl) showed the most potent activity against MCF-7 cell lines. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Formula: C8H4N2O4).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Formula: C8H4N2O4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles