Category: 113162-36-0

Electric Literature of C10H8FNO2On May 31, 1988, Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; Smith, Colin F. C.; Stillings, Michael R.; Welbourn, Anthony P. published an article in Journal of Medicinal Chemistry. The article was 《Indoline analogs of idazoxan: potent α2-antagonists and α1-agonists》. The article mentions the following:

The synthesis and α-adrenergic activity of a series of substituted 2-imidazolinylindolines are described. Substitution in the indoline ring generated compounds with a spectrum of adrenoreceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent. Many of the derivatives possess greater presynaptic antagonist potency than the corresponding benzodioxan, dihydrobenzofuran, and indan analogs; however, this α2-antagonism is often accompanied by α1-agonist activity. It was not possible to sep. α2-antagonist from α1-agonist properties in this series. Compounds of most interest proved to be the N-Et, 5-chloro-N-Me, and 5-chloro-N-Et derivatives, all being potent α2-antagonists and α1-agonists. Substitution at the 4- and 7-position of the indoline ring generally gave compounds with nonselective agonist properties. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0Electric Literature of C10H8FNO2)

Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Electric Literature of C10H8FNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Synthesis and crystal structures of fluorinated indoles as RNA analogues》 was published in Collection Symposium Series in 2005. These research results belong to Bozilovic, Jelena; Bats, Jan W.; Engels, Joachim W.. Category: indole-building-block The article mentions the following:

Fluorinated indole nucleosides I (R1 = H, R2 = F; R1 = R2 = F; R1 = H, R2 = H) have been synthesized as RNA nucleosides. We crystallized two of the synthesized nucleosides. The sugar ring of I (R1 = H, R2 = F) has between a C3′-endo envelope and C2′-exo,C3′-endo half-chair conformation. The sugar ring of I (R1 = R2 = F) has a C3′-endo envelope conformation. Both fluoroindole groups are essentially planar. Neighboring layers of both crystals are connected by C-H···F-C interactions with bond distances of 2,39 and 2.40Å with C-H-F angles of 155°. All the synthesized nucleosides are going to be incorporated in RNA oligonucleotides and UV-melting profiles and CD-spectra are going to be determined The experimental process involved the reaction of Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0Category: indole-building-block)

Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C10H8FNO2On September 30, 2007 ,《Synthesis of Fluorinated Indoles as RNA Analogues》 was published in Nucleosides, Nucleotides & Nucleic Acids. The article was written by Bozilovic, Jelena; Engels, Joachim W.. The article contains the following contents:

Nucleoside analogs, e.g. I, are chem. means to investigate hydrogen bonds, base stacking, and solvation as the three predominant forces that are responsible for the stability of secondary structure of nucleic acids. To obtain deeper insight into the contributions of these interactions to RNA stability apart from the ones exerted by the predominant nucleosides we decided to synthesize some novel nucleic acid analogs where the nucleobases are replaced by fluoroindoles. Fluorinated indoles can be compared to fluorinated benzimidazoles to determine the role of nitrogen in five membered ring system. The synthesis of fluoroindole ribonucleosides is described here. In the experiment, the researchers used Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0COA of Formula: C10H8FNO2)

Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).COA of Formula: C10H8FNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles