Category: 115666-47-2

115666-47-2, 6-Iodo-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Iodo-1H-indole (100 mg, 0.41 mmol,1.00 equiv) was dissolved in dry THF (10 mL) under N2 and cooled to -78 C. At thistemperature a 1.0 M solution of LHMDS in THF (450 muL, 0.45 mmol, 1.10 equiv) was addedand the reaction was stirred for 30 min before TIPSCl (95 muL, 0.43 mmol, 1.05 equiv) wasadded. After stirring for 20 min at -78 C and 1 h at room temperature the reaction wasquenched with saturated NH4Cl (1 mL). Water (5 mL) was added and the reaction mixturewas extracted with EtOAc (3 x 10 mL), dried, filtered and concentrated. Flash columnchromatography on silica gel using petroleum ether, primed with petroleum ether/NEt3(100:1) as the eluent afforded the product as colorless oil (152 mg, 0.38 mmol, 93%)., 115666-47-2

As the paragraph descriping shows that 115666-47-2 is playing an increasingly important role.

Reference£º
Article; Marsch, Nils; Kock, Mario; Lindel, Thomas; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 334 – 342;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115666-47-2,6-Iodo-1H-indole,as a common compound, the synthetic route is as follows.

6-Iodo-1H-indole (2, 1.513 g,6.30 mmol, 1.00 equiv, [S2]) was dissolved in CH2Cl2 (90 mL). Boc2O (2.063 g, 9.45 mmol,1.50 equiv) and DMAP (154 mg, 1.26 mmol, 20 mol %) were added and the mixture wasstirred at room temperature overnight. The solvent was evaporated and the crude productwas subjected to column chromatography using petroleum ether/EtOAc (15:1) as the eluentto yield N-Boc-6-iodoindole (3, 2.117 g, 6.17 mmol, 98%) as colorless solid.

115666-47-2, The synthetic route of 115666-47-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Marsch, Nils; Kock, Mario; Lindel, Thomas; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 334 – 342;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles