Category: 118414-82-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118414-82-7,MK-886,as a common compound, the synthetic route is as follows.

Step 1: 3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethyl-propionyl chloride To 3-[3-tert-butylsulfanyl-1-(4-chloro-benzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethyl-propionic acid (prepared according to the procedures described in U.S. Pat. No. 5,081,138 issued Jan. 14, 1992; 0.25 g, 0.53 mmol) suspended in CH2Cl2 (5 mL) was added oxalyl chloride (48 uL, 0.56 mmol) and catalytic DMF. The reaction was stirred at room temperature for 3 hours, and then concentrated to give I-1, which was used without further purification.

118414-82-7, As the paragraph descriping shows that 118414-82-7 is playing an increasingly important role.

Reference：
Patent; Amira Pharmaceuticals, Inc.; US2007/105866; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118414-82-7,MK-886,as a common compound, the synthetic route is as follows.,118414-82-7

To 3-[3-tert-butylsulfanyl-l-(4-chloro-benzyl)-5-isopropyl-lH-indol-2-yl]-2,2-dimethyl- propionic acid (prepared according to the procedures described in US patent 5,081, 138 issued Jan 14, 1992; 0.25g, 0.53mmol) suspended in CH2CI2 (5mL) was added oxalyl chloride (48uL, 0.56mmol) and catalytic DMF. The reaction was stirred at room temperature for 3 hours, and then concentrated to give 1-1, which was used without further purification.

118414-82-7 MK-886 3651377, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; AUTOIMMUNE PHARMA LLC; BENISON, Jeffrey; (157 pag.)WO2018/152405; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

118414-82-7, MK-886 is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 3-[3-rert-butylsulfanyl-1-(4-chloro-benzyl)-5-isopropyl- lH-indol-2-yl]-2,2-dimethyl- propionic acid (1.26 mmol) and 6-bromohexyl nitrate (F. Conrad Engelhardt et a, J. Org. Chem., 2006, 71, 480-491; 1.4 mmol) in DMF (5 ml) was added CsCO3 (6 mmol). The mixture was stirred at room temperature over night. H2O was added and the reaction mixture was extracted with ethyl acetate. The extracts were washed with brine, dried over Na2SO4, filtered, and the solvent was evaporated under reduced pressure. The residue obtained was purified by silica gel chromatography (25% EtOAc in hexanes) to give the desired product.[0400] 1H NMR delta 7.63 (s, IH), 7.19 (d, 2H), 7.02 (s, 2H), 6.74 (d, 2H), 5.32 (s, 2H), 4.38 (t, 2H), 3.97 (t, 2H),3.25 (s, 2H), 3.01 (m, IH), 1.62-1.15 (m, 29H)., 118414-82-7

The synthetic route of 118414-82-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AMIRA PHARMACEUTICALS, INC.; WO2008/67566; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles