Category: 1186663-64-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1186663-64-8,3-Bromo-1H-indole-4-carbonitrile,as a common compound, the synthetic route is as follows.

3-Bromo?l H-mdole-4-carboimrile (l-146a: 5OU mg, 2.272 mmol) was added dropwise. tupsilon a stirred mixture of NaI 1 (0.218 g, 9.0833 mmol) in dry DMl- ( 15 ml ) at OT over a period of 10 minutes. This was followed b>- the addition of methyl iodide and the resulting mixture was stirred at O0C for -? hours. The reaction was monitored by Tl, C (10% cth) lacctatc in hcxane). The reaction mixture was quenched with ice water: the precipitate formed was collected and dried to afford 0.400 g of the crude product.1H NMR (CDCl,, 300 MH/): delta 7.8-7.0 (m, 411), 3.82 (s, 3H)

1186663-64-8, The synthetic route of 1186663-64-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra; WO2010/149755; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1186663-64-8, 3-Bromo-1H-indole-4-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1186663-64-8, Step 2: Preparation of Intermediate 3-Bromo-1-methyl-1H-indole-4-carbonitrile (I-146b)3-Bromo-1H-indole-4-carbonitrile (I-146a: 500 mg, 2.272 mmol) was added dropwise to a stirred mixture of NaH (0.218 g, 9.0833 mmol) in dry DMF (15 mL) at 0 C. over a period of 10 minutes. This was followed by the addition of methyl iodide and the resulting mixture was stirred at 0 C. for 2 hours. The reaction was monitored by TLC (10% ethylacetate in hexane). The reaction mixture was quenched with ice water; the precipitate formed was collected and dried to afford 0.400 g of the crude product.1H NMR (CDCl3, 300 MHz): delta 7.8-7.0 (m, 4H), 3.82 (s, 3H)

As the paragraph descriping shows that 1186663-64-8 is playing an increasingly important role.

Reference：
Patent; Novartis AG; US2010/331326; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles