With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118959-44-7,1-Methyl-1H-indole-3-carboxamide,as a common compound, the synthetic route is as follows.
General procedure: Lawesson?s reagent (0.38 g, 0.96 mmol for compound 7f or 0.80 g, 2 mmol for compounds 8a-f and 9a-e) was added to a solution of appropriate derivatives 7f (0.17 g, 0.95 mmol) or 8a-f and 9a-e (4 mmol) in anhydrous toluene or benzene (20 mL). The mixture was heated at reflux under nitrogen atmosphere for 0.5-24 h. After cooling the solvent was evaporated under reduced pressure and the residue was purified by column chromatography using ethyl acetate (for compound 10f), dichloromethane /ethyl acetate (98/2) (for compounds 11a-f) or dichloromethane (for compounds 12a-e) as eluent. For compounds 10f, 11a-f and 12a,c-e see supplementary material., 118959-44-7
118959-44-7 1-Methyl-1H-indole-3-carboxamide 823187, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Article; Carbone; Pennati; Barraja; Montalbano; Parrino; Spano; Lopergolo; Sbarra; Doldi; Zaffaroni; Cirrincione; Diana; Current Medicinal Chemistry; vol. 21; 14; (2014); p. 1654 – 1666;,
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